Role of transforming growth factor-β in airway remodelling in bronchiolitis obliterans.

IF 1.8 4区生物学 Q4 CELL BIOLOGY

Growth factors Pub Date : 2023-10-01 Epub Date: 2023-07-24 DOI:10.1080/08977194.2023.2239356

Ziwei Wang

引用次数: 0

Abstract

Airway remodelling is the main pathological mechanism of bronchiolitis obliterans (BO). Several studies have found that transforming growth factor-β (TGF-β) expression is increased in BO during airway remodelling, where it plays an important role in various biological processes by binding to its receptor complex to activate multiple signalling proteins and pathways. This review examines the role of TGF-β in airway remodelling in BO and its potential as a therapeutic target, highlighting the mechanisms of TGF-β activation and signalling, cellular targets of TGF-β actions, and research progress in TGF-β signalling and TGF-β-mediated processes.

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转化生长因子-β在闭塞性细支气管炎气道重塑中的作用。

气道重塑是闭塞性细支气管炎（BO）的主要病理机制。几项研究发现，在气道重塑过程中，转化生长因子-β（TGF-β）在BO中的表达增加，通过与受体复合物结合激活多种信号蛋白和途径，在各种生物学过程中发挥重要作用。本文综述了转化生长因子-β在BO气道重塑中的作用及其作为治疗靶点的潜力，重点介绍了转化生长蛋白-β激活和信号传导的机制、转化生长因子β作用的细胞靶点，以及转化生长因子/β信号传导和转化生长因子介导的过程的研究进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Growth factors 生物-内分泌学与代谢

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Growth Factors is an international and interdisciplinary vehicle publishing new knowledge and findings on the regulators of cell proliferation, differentiation and survival. The Journal will publish research papers, short communications and reviews on current developments in cell biology, biochemistry, physiology or pharmacology of growth factors, cytokines or hormones which improve our understanding of biology or medicine. Among the various fields of study topics of particular interest include: •Stem cell biology •Growth factor physiology •Structure-activity relationships •Drug development studies •Clinical applications