Preserving the discreteness of deficits during coding leads to a lower frailty index in individuals living in long-term care

IF 5.3 3区医学 Q2 CELL BIOLOGY

Mechanisms of Ageing and Development Pub Date : 2023-09-01 DOI:10.1016/j.mad.2023.111851

Brian Greeley , Hilary Low , Ronald Kelly , Robert McDermid , Xiaowei Song

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引用次数: 0

Abstract

This study assesses two coding approaches on the frailty index (FI).

Two FI were calculated using 43 variables from 29,758 older adults (84.6 ± 8 years old; 64 % female) in long-term care. Scores were coded as 0, 0.5, or 1 regardless of the number of levels (grouped), or preserved (e.g., a 4 level variable was coded as 0, 0.33, 0.67, or 1; discrete). Grouped and discrete FI were compared with each ordinal variable removed but all other ordinal variables included. This was repeated until 28 unique (14 grouped, 14 discrete) FI had been constructed each with one ordinal variable removed per FI. FI was correlated to age and mortality separated by sex.

The median grouped (0.302 (0.221–0.372)) was higher relative to the discrete (0.237 (0.170–0.307)) FI. The discrete (r = 0.91, r = 0.87) and grouped (r = 0.93, r = 0.87) FI showed similar relationships to age and mortality. Removal of any ordinal variable reduced grouped FI by 0.004 or 0.016, whereas removal led to both increases (range: 0.003–0.001) and reductions (range: 0.002–0.008) for discrete FI.

A grouped approach inflates FI. A discrete approach provides a more accurate measure of frailty.

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在编码过程中保持缺陷的离散性可以降低长期护理个体的脆弱指数

本研究评估两种编码方法对脆弱指数(FI)。使用来自29,758名老年人(84.6±8岁;(64%为女性)接受长期护理。得分被编码为0、0.5或1，无论水平(分组)的数量，或保留(例如，一个4水平变量被编码为0、0.33、0.67或1;离散)。将分组和离散FI进行比较，去除每个顺序变量，但包括所有其他顺序变量。重复这一过程，直到构建了28个独特的(14个分组，14个离散)FI，每个FI都删除了一个顺序变量。FI与性别分开的年龄和死亡率相关。组中位数(0.302(0.221-0.372))高于离散FI(0.237(0.170-0.307))。离散FI (r = 0.91, r = 0.87)和分组FI (r = 0.93, r = 0.87)与年龄和死亡率的关系相似。去除任何有序变量将分组FI降低0.004或0.016，而去除离散FI会导致增加(范围:0.003-0.001)和减少(范围:0.002-0.008)。分组方法使FI膨胀。离散的方法提供了更精确的脆弱性度量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mechanisms of Ageing and Development 医学-老年医学

CiteScore

11.10

自引率

1.90%

发文量

审稿时长

32 days

期刊介绍： Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms. Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.