Acceptability of PC-1005 Gel Administered Rectally to HIV-1 Seronegative Adults at Three Different Volume Levels (MTN-037).

IF 1.6 4区医学 Q2 EDUCATION & EDUCATIONAL RESEARCH

Aids Education and Prevention Pub Date : 2022-08-01 DOI:10.1521/aeap.2022.34.4.257

José A Bauermeister, Ryan C Tingler, Ken Ho, Rachel Scheckter, Tara McClure, Jontraye Davis, Jeanna Piper, Barbara A Friedland, Stacey Edick, Mei Song, Yuqing Jiao, Craig W Hendrix, Craig Hoesley

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Abstract

Multipurpose prevention technologies (MPT) have been increasingly researched for their dual-purpose preventative properties against HIV and other STIs. The acceptability of PC-1005, a topical MPT candidate, was explored among men and women participating in the MTN-037 Phase I trial at two U.S. sites (Pittsburgh, PA, and Birmingham, AL). We triangulated quantitative and qualitative assessments of the acceptability of three volumes (4 mL, 16 mL, 32 mL) of PC-1005 administered rectally (N = 12; 6 males, 6 females). Participants rated overall gel acceptability on a scale of 1-10, with a median of 7.17 (SD = 2.04) and had positive feelings about all three dose volumes, citing them to be very comfortable or comfortable (dose 1 = 91.7%; dose 2 = 91.7%; dose 3 = 83.3%). High acceptability of and comfort with all three dose volumes shows promise for PC-1005 as an MPT to prevent HIV and STIs, warranting future clinical development.

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PC-1005凝胶在三种不同体积水平下经直肠给药于HIV-1血清阴性成人的可接受性（MTN-037）。

多用途预防技术（MPT）因其对艾滋病毒和其他性传播感染的双重预防特性而受到越来越多的研究。在美国两个地点（宾夕法尼亚州匹兹堡和阿拉巴马州伯明翰）参与MTN-037 I期试验的男性和女性中，对局部MPT候选物PC-1005的可接受性进行了探讨。我们对经直肠给药的三体积（4 mL、16 mL、32 mL）PC-1005（N=12；6名男性，6名女性）的可接受性进行了定量和定性评估。参与者对凝胶的总体可接受性进行了1-10分的评分，中位数为7.17（SD=2.04），并对所有三个剂量量表都有积极的感觉，认为它们非常舒适或舒适（剂量1=91.7%；剂量2=91.7%；剂量3=83.3%）。所有三个量表的高可接受性和舒适性表明PC-1005有望成为预防艾滋病毒和性传播感染的MPT，保证了未来的临床发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aids Education and Prevention Multiple-

CiteScore

2.20

自引率

5.60%

发文量

期刊介绍： Presenting state-of-the-art research and information, AIDS Education and Prevention is a vital addition to the library collections of medical schools, hospitals, and other institutions and organizations with HIV/AIDS research programs. The journal integrates public health, psychosocial, sociocultural, and public policy perspectives on issues of key concern nationally and globally.