Kawasaki Disease Associated with SARS-CoV2 in a Pair of Triplets.

IF 1.1 4区医学 Q4 ALLERGY

Pediatric Allergy Immunology and Pulmonology Pub Date : 2023-09-01 Epub Date: 2023-07-19 DOI:10.1089/ped.2023.0045

Luisa Berenise Gamez-Gonzalez, Luis Xochihua-Díaz, Moises Ramirez-Lopez, Marcela Colmenero-Rascon, Emiy Yokoyama-Rebollar, Itzya Hernández-Santiago, Abner Bojalil-Cabildo, Marco Antonio Yamazaki-Nakashimada

引用次数: 0

Abstract

The etiology of Kawasaki disease (KD) and its precise genetic basics remain unknown. Genetic variants affecting immunity have been found in some patients. The occurrence of KD in siblings is rare, but KD pedigrees with multiple affected members have been described in Japan and North America. Cases in twins have been documented. We report 2 pairs of trizygotic triplets who developed KD associated with SARS-CoV2 infection from 2 different families. Our cases show that KD is multifactorial in origin, and both infectious etiology (particularly SARS-CoV2 as in our cases) and genetic factors are relevant in the disease.

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川崎病与严重急性呼吸系统综合征冠状病毒2型在一对三联病例中的相关性。

川崎病的病因及其确切的遗传基础尚不清楚。在一些患者身上发现了影响免疫力的基因变异。KD在兄弟姐妹中的发生是罕见的，但在日本和北美已经描述了具有多个受影响成员的KD谱系。双胞胎病例已有文献记载。我们报道了来自两个不同家庭的2对三合子三胞胎，他们患上了与严重急性呼吸系统综合征冠状病毒2型感染相关的KD。我们的病例表明，KD的起源是多因素的，传染性病因（尤其是像我们的病例中的严重急性呼吸系统综合征冠状病毒2型）和遗传因素都与该疾病有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Allergy Immunology and Pulmonology ALLERGY-IMMUNOLOGY

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pediatric Allergy, Immunology, and Pulmonology is a peer-reviewed journal designed to promote understanding and advance the treatment of respiratory, allergic, and immunologic diseases in children. The Journal delivers original translational, clinical, and epidemiologic research on the most common chronic illnesses of children—asthma and allergies—as well as many less common and rare diseases. It emphasizes the developmental implications of the morphological, physiological, pharmacological, and sociological components of these problems, as well as the impact of disease processes on families. Pediatric Allergy, Immunology, and Pulmonology coverage includes: -Functional and genetic immune deficiencies- Interstitial lung diseases- Both common and rare respiratory, allergic, and immunologic diseases- Patient care- Patient education research- Public health policy- International health studies