Exercise as a Therapy to Maintain Telomere Function and Prevent Cellular Senescence.

IF 4.9 2区医学 Q1 PHYSIOLOGY

Exercise and Sport Sciences Reviews Pub Date : 2023-10-01 Epub Date: 2023-06-07 DOI:10.1249/JES.0000000000000324

Jeongjin J Kim, Alexander Ahn, Jeffrey Ying, Evan Hickman, Andrew T Ludlow

引用次数: 0

Abstract

Exercise transiently impacts the expression, regulation, and activity of TERT/telomerase to maintain telomeres and protect the genome from insults. By protecting the telomeres (chromosome ends) and the genome, telomerase promotes cellular survival and prevents cellular senescence. By increasing cellular resiliency, via the actions of telomerase and TERT, exercise promotes healthy aging.

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运动作为一种维持端粒功能和防止细胞衰老的治疗方法。

运动会短暂影响TERT/端粒酶的表达、调节和活性，以维持端粒并保护基因组免受损伤。端粒酶通过保护端粒（染色体末端）和基因组，促进细胞存活并防止细胞衰老。通过端粒酶和TERT的作用增加细胞弹性，运动促进健康衰老。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Exercise and Sport Sciences Reviews 社会科学-生理学

CiteScore

10.70

自引率

1.80%

发文量

期刊介绍： Exercise and Sport Sciences Reviews made the transition from an annual hardcover series book to a quarterly journal in January 2000. The mission of this American College of Sports Medicine publication is to provide premier quarterly reviews of the most contemporary scientific, medical, and research-based topics emerging in the field of sports medicine and exercise science. The publication strives to provide the most relevant, topical information to students, professors, clinicians, scientists, and professionals for practical and research applications.