Incidence and predictors of attrition among adults receiving first line anti-retroviral therapy at public health facility in Adea Berga district, Oromia, Ethiopia.

IF 1.6 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Journal of Public Health Research Pub Date : 2023-07-01 DOI:10.1177/22799036231197194

Seifu Kassa, Tariku Dingeta, Tesfaye Gobana, Tadesse Dufera

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引用次数: 0

Abstract

Background: According to current estimates, there are 665,723 people in Ethiopia who have human immunodeficiency syndrome. As Ethiopia inches closer to attaining the 95/95/95 targets for treatment coverage and reaching epidemic control, however, attrition from anti-retroviral treatment is still one of the key programmatic challenges.

Objective: To assess the incidence of attrition rate and its predictors among adult HIV patients receiving anti retro viral treatment at Public Health Facility in Adea Berga/Enchini District.

Method: A 6-year (June 28, 2015 to June 27, 2021) institution-based retrospective cohort study was used to recruit 540 study participants by using simple random sampling. Data were obtained from chart review, coded, entered into Epi Data, and exported to Stata 14.2 software for analysis. At least 1 month missed appointment is considered as attrition and the predictors of attrition were identified using bivariable and multivariable Cox proportional hazard models and an adjusted hazard ratio (AHR). Bivariate and multivariate analyses were conducted to find predictors of attrition, p-value < 0.05 was considered statistically significant.

Results: From the total 540 study participant, 158 (29.26%) patients were discontinuing from follow up making the incidence rate of attrition 9.50 per 100 person years .Being WHO clinical stage III or IV (AHR = 1.96,), non-practice of Appointment spacing model (AHR = 3.98), poor or fair ART adherence level (AHR = 6.47), age groups (15-24) years (AHR = 1.73) and Others ART linkage points[index case testing, tuberculosis clinic and referral from private/public health institutions] (AHR = 1.76) were significantly associated.

Conclusions: The study showed that the incidence of attrition among adults receiving antiretroviral therapy was high. Patient sociodemographic, clinical, and treatment-related factors were significantly associated with patients on ART.

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埃塞俄比亚奥罗米亚阿迪贝加区公共卫生机构接受一线抗逆转录病毒治疗的成年人的发病率和损耗预测因素。

背景:根据目前的估计，埃塞俄比亚有665,723人患有人类免疫缺陷综合征。然而，随着埃塞俄比亚逐步接近实现治疗覆盖率和流行病控制的95/95/95目标，抗逆转录病毒治疗的损耗仍然是主要的方案挑战之一。目的:了解Adea Berga/Enchini区公共卫生机构接受抗逆转录病毒治疗的成年HIV患者的损耗率及其预测因素。方法:采用简单随机抽样的方法，采用为期6年(2015年6月28日- 2021年6月27日)的机构回顾性队列研究，招募540名研究对象。从图表评审中获得数据，编码，输入Epi Data，导出到Stata 14.2软件进行分析。至少1个月未预约被视为减员，减员的预测因素采用双变量和多变量Cox比例风险模型和调整风险比(AHR)确定。进行了双变量和多变量分析，以寻找流失的预测因子，p值。在总共540名研究参与者中，158例(29.26%)患者停止随访，使得每100人年的流失率为9.50例。WHO临床III期或IV期(AHR = 1.96)，未采用就诊间隔模型(AHR = 3.98)，较差或一般的ART依从性(AHR = 6.47)，年龄组(15-24岁)(AHR = 1.73)和其他ART联系点[指数病例检验]，结核病门诊和私人/公共卫生机构转诊](AHR = 1.76)显著相关。结论:研究表明，在接受抗逆转录病毒治疗的成年人中，损耗的发生率很高。患者的社会人口学、临床和治疗相关因素与接受抗逆转录病毒治疗的患者显著相关。

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来源期刊

Journal of Public Health Research PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

3.70

自引率

4.30%

发文量

116

审稿时长

10 weeks

期刊介绍： The Journal of Public Health Research (JPHR) is an online Open Access, peer-reviewed journal in the field of public health science. The aim of the journal is to stimulate debate and dissemination of knowledge in the public health field in order to improve efficacy, effectiveness and efficiency of public health interventions to improve health outcomes of populations. This aim can only be achieved by adopting a global and multidisciplinary approach. The Journal of Public Health Research publishes contributions from both the “traditional'' disciplines of public health, including hygiene, epidemiology, health education, environmental health, occupational health, health policy, hospital management, health economics, law and ethics as well as from the area of new health care fields including social science, communication science, eHealth and mHealth philosophy, health technology assessment, genetics research implications, population-mental health, gender and disparity issues, global and migration-related themes. In support of this approach, JPHR strongly encourages the use of real multidisciplinary approaches and analyses in the manuscripts submitted to the journal. In addition to Original research, Systematic Review, Meta-analysis, Meta-synthesis and Perspectives and Debate articles, JPHR publishes newsworthy Brief Reports, Letters and Study Protocols related to public health and public health management activities.