Association between the High-Sensitivity C-Reactive Protein/Albumin Ratio and New-Onset Chronic Kidney Disease in Chinese Individuals.

IF 2.3 4区医学 Q2 UROLOGY & NEPHROLOGY

Nephron Pub Date : 2024-01-01 Epub Date: 2023-09-12 DOI:10.1159/000534034

Zihao Zhang, Peipei Liu, Ling Yang, Naihui Zhao, Wenli Ou, Xiaofu Zhang, Yinggen Zhang, Shuohua Chen, Shouling Wu, Xiuhong Yang

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引用次数: 0

Abstract

Introduction: Inflammation is associated with development of chronic kidney disease (CKD). However, the association of the high-sensitivity C-reactive protein (hs-CRP)/albumin ratio (CAR) on the risk of CKD in the general population is unknown. This study explored the relationship between the CAR and CKD and the ability of this ratio to predict CKD in the general population.

Methods: A total of 47,472 participants in the Kailuan study who met the inclusion criteria in 2010 were selected and grouped using the quartile method. A Cox proportional hazard regression model was used to evaluate the association of the CAR on the risk of CKD. The C-index, net reclassification index (NRI), and overall identification index (IDI) were calculated to evaluate the ability of the CAR to predict CKD.

Results: During a follow-up of 378,383 person-years, CKD events occurred in 6,249 study participants (13.16%). The Cox proportional hazard regression model showed that the hazard ratio (95% confidence interval) for CKD events was 1.18 (1.10-1.28) in the Q3 group and 1.42 (1.32-1.53) in the Q4 group when compared with the Q1 group. Compared with the single index, the C-index, NRI, and IDI values were significantly improved when the CAR was added for prediction of risk of CKD.

Conclusions: A higher CAR was an independent risk factor for CKD. The ability of the CAR to predict CKD was better than that of hs-CRP or albumin. The CAR provides an important reference index for predicting the risk of CKD.

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中国人的高敏 C 反应蛋白/白蛋白比值与新发慢性肾脏病之间的关系

导言：炎症与慢性肾脏病（CKD）的发展有关。然而，高敏 C 反应蛋白（hs-CRP）/白蛋白比值（CAR）与普通人群患慢性肾脏病风险的关系尚不清楚。本研究探讨了高敏C反应蛋白/白蛋白比值与慢性阻塞性肺病之间的关系，以及该比值在普通人群中预测慢性阻塞性肺病的能力：方法：选取 2010 年开滦研究中符合纳入标准的 47,472 名参与者，采用四分位法进行分组。采用 Cox 比例危险回归模型评估 CAR 与 CKD 风险的相关性。计算了C指数、净再分类指数（NRI）和总体识别指数（IDI），以评估CAR预测CKD的能力：在 378,383 人年的随访期间，6,249 名研究参与者（13.16%）发生了 CKD 事件。考克斯比例危险回归模型显示，与第一季度组相比，第三季度组发生 CKD 事件的危险比（95% 置信区间）为 1.18（1.10-1.28），第四季度组为 1.42（1.32-1.53）。与单一指数相比，加入CAR预测CKD风险时，C指数、NRI和IDI值均有明显改善：结论：较高的 CAR 是 CKD 的独立风险因素。结论：较高的 CAR 值是 CKD 的独立风险因素，CAR 预测 CKD 的能力优于 hs-CRP 或白蛋白。CAR 为预测 CKD 风险提供了一个重要的参考指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nephron UROLOGY & NEPHROLOGY-

CiteScore

5.00

自引率

0.00%

发文量

期刊介绍： ''Nephron'' comprises three sections, which are each under the editorship of internationally recognized leaders and served by specialized Associate Editors. Apart from high-quality original research, ''Nephron'' publishes invited reviews/minireviews on up-to-date topics. Papers undergo an innovative and transparent peer review process encompassing a Presentation Report which assesses and summarizes the presentation of the paper in an unbiased and standardized way.