Resilience in Newly Diagnosed Breast Cancer Women: The Predictive Role of Diurnal Cortisol and Social Support.

IF 1.9 4区 医学 Q2 NURSING
Biological research for nursing Pub Date : 2024-01-01 Epub Date: 2023-07-21 DOI:10.1177/10998004231190074
Ibane Aizpurua-Perez, Amaia Arregi, David Gonzalez, Patricia Macia, Gurutze Ugartemendia, Ainitze Labaka, Nerea Zabalza, Joana Perez-Tejada
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引用次数: 0

Abstract

Background: Breast cancer is currently the most prevalent malignancy among women. Psychological resilience is an important factor that diminishes the stress-related emotional and psychosocial disturbances triggered when receiving the diagnosis. Furthermore, resilience appears to be associated with cortisol, the hormonal end-product of the hypothalamic-pituitary-adrenal axis; however, further studies are needed due to the mixed results reported. Thus, we aim to examine the predictive role of social support and cortisol in resilience among breast cancer patients.

Methods: A total of 132 women with primary breast cancer completed the Medical Outcomes Study-Social Support Survey (MOS-SSS) and the Resilience Scale (RS-14) and provided four salivary samples for the estimation of participants' total daily cortisol production, for which the formula of the area under the curve with respect to the ground (AUCg) was applied. Moderation analyses were performed to study the influence of social support and AUCg on psychological resilience levels.

Results: The regression analyses showed a direct significant effect for the emotional support subscale of MOS-SSS on resilience and the interaction between emotional support and AUCg was also found to be statistically significant. Specifically, the conditional effect of emotional support on resilience was found to be significant at middle (M = 3.08; p < .05) and low levels (M = .59; p < .001) of AUCg.

Conclusions: Our results suggest that newly diagnosed breast cancer women with middle and low diurnal cortisol profiles may benefit more from emotional support based-interventions while women with high diurnal cortisol may need more individualized therapies.

新诊断乳腺癌妇女的恢复力:日皮质醇和社会支持的预测作用。
背景:乳腺癌是目前女性中最常见的恶性肿瘤。心理弹性是减少接受诊断时引发的与压力相关的情绪和社会心理障碍的重要因素。此外,恢复力似乎与皮质醇有关,皮质醇是下丘脑-垂体-肾上腺轴的激素终产物;然而,由于报告的结果不一,需要进一步的研究。因此,我们的目的是研究社会支持和皮质醇在乳腺癌患者恢复力中的预测作用。方法:对132名原发性乳腺癌妇女进行医学结局研究-社会支持调查(MOS-SSS)和恢复力量表(RS-14),并提供4个唾液样本,用于估计参与者的每日总皮质醇产量,其中曲线下面积相对于地面(AUCg)公式应用。采用调节分析研究社会支持和AUCg对心理弹性水平的影响。结果:回归分析显示,情绪支持分量表对心理弹性有直接显著影响,情绪支持分量表与AUCg的交互作用也有统计学意义。其中,情绪支持对心理弹性的条件效应在中等水平显著(M = 3.08;p < 0.05)和低水平(M = .59;p < 0.001)。结论:我们的研究结果表明,新诊断的乳腺癌女性中、低皮质醇日谱可能从基于情感支持的干预中获益更多,而高皮质醇日谱的女性可能需要更多的个性化治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.10
自引率
4.00%
发文量
58
审稿时长
>12 weeks
期刊介绍: Biological Research For Nursing (BRN) is a peer-reviewed quarterly journal that helps nurse researchers, educators, and practitioners integrate information from many basic disciplines; biology, physiology, chemistry, health policy, business, engineering, education, communication and the social sciences into nursing research, theory and clinical practice. This journal is a member of the Committee on Publication Ethics (COPE)
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