Potential of mesenchymal stem cell-derived conditioned medium/secretome as a therapeutic option for ocular diseases.

IF 2.4 4区医学 Q4 CELL & TISSUE ENGINEERING

Regenerative medicine Pub Date : 2023-10-01 Epub Date: 2023-09-13 DOI:10.2217/rme-2023-0089

Wesley Harrisson Bouche Djatche, Huimin Zhu, Wenlei Ma, Yue Li, Ziang Li, Hong Zhao, Zhizhen Liu, Hua Qiao

引用次数: 0

Abstract

Research has shown that the therapeutic effect of mesenchymal stem cells (MSCs) is partially due to its secreted factors as opposed to the implantation of the cells into the treated tissue or tissue replacement. MSC secretome, especially in the form of conditioned medium (MSC-CM) is now being explored as an alternative to MSCs transplantation. Despite the observed benefits of MSC-CM, only a few clinical trials have evaluated it and other secretome components in the treatment of eye diseases. This review provides insight into the potential therapeutic use of MSC-CM in eye conditions, such as corneal diseases, dry eye, glaucoma, retinal diseases and uveitis. We discuss the current evidence, some limitations, and the progress that remains to be achieved before clinical translation becomes possible.

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间充质干细胞衍生的条件培养基/分泌组作为眼部疾病治疗选择的潜力。

研究表明，间充质干细胞（MSC）的治疗效果部分是由于其分泌因子，而不是将细胞植入治疗过的组织或组织替代物中。MSC分泌组，特别是以条件培养基（MSC-CM）的形式，目前正在被探索作为MSC移植的替代品。尽管观察到MSC-CM的益处，但只有少数临床试验评估了它和其他分泌组分在治疗眼病中的作用。这篇综述深入了解了MSC-CM在角膜疾病、干眼症、青光眼、视网膜疾病和葡萄膜炎等眼部疾病中的潜在治疗用途。我们讨论了目前的证据、一些局限性，以及在临床翻译成为可能之前有待取得的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Regenerative medicine 医学-工程：生物医学

CiteScore

4.20

自引率

3.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Regenerative medicine replaces or regenerates human cells, tissue or organs, to restore or establish normal function*. Since 2006, Regenerative Medicine has been at the forefront of publishing the very best papers and reviews covering the entire regenerative medicine sector. The journal focusses on the entire spectrum of approaches to regenerative medicine, including small molecule drugs, biologics, biomaterials and tissue engineering, and cell and gene therapies – it’s all about regeneration and not a specific platform technology. The journal’s scope encompasses all aspects of the sector ranging from discovery research, through to clinical development, through to commercialization. Regenerative Medicine uniquely supports this important area of biomedical science and healthcare by providing a peer-reviewed journal totally committed to publishing the very best regenerative medicine research, clinical translation and commercialization. Regenerative Medicine provides a specialist forum to address the important challenges and advances in regenerative medicine, delivering this essential information in concise, clear and attractive article formats – vital to a rapidly growing, multidisciplinary and increasingly time-constrained community. Despite substantial developments in our knowledge and understanding of regeneration, the field is still in its infancy. However, progress is accelerating. The next few decades will see the discovery and development of transformative therapies for patients, and in some cases, even cures. Regenerative Medicine will continue to provide a critical overview of these advances as they progress, undergo clinical trials, and eventually become mainstream medicine.