Medicinal plants as a source of antiparasitics: an overview of experimental studies.

IF 4.9 4区 医学 Q1 PARASITOLOGY
Pathogens and Global Health Pub Date : 2023-09-01 Epub Date: 2023-02-20 DOI:10.1080/20477724.2023.2179454
Sandamalie Ranasinghe, Anthony Armson, Alan J Lymbery, Alireza Zahedi, Amanda Ash
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引用次数: 0

Abstract

Despite advances in modern human and veterinary medicine, gastrointestinal (GI) parasitic infections remain a significant health issue worldwide, mainly in developing countries. Increasing evidence of the multi-drug resistance of these parasites and the side effects of currently available synthetic drugs have led to increased research on alternative medicines to treat parasitic infections. The exploration of potential botanical antiparasitics, which are inexpensive and abundant, may be a promising alternative in this context. This study summarizes the in vitro/in vivo antiparasitic efficacy of different medicinal plants and their components against GI parasites. Published literature from 1990-2020 was retrieved from Google Scholar, Web of Science, PubMed and Scopus. A total of 68 plant species belonging to 32 families have been evaluated as antiparasitic agents against GI parasites worldwide. The majority of studies (70%) were conducted in vitro. Most plants were from the Fabaceae family (53%, n = 18). Methanol (37%, n = 35) was the most used solvent. Leaf (22%, n = 16) was the most used plant part, followed by seed and rhizome (each 12%, n = 9). These studies suggest that herbal medicines hold a great scope for new drug discoveries against parasitic diseases and that the derivatives of these plants are useful structures for drug synthesis and bioactivity optimization.

药用植物作为抗寄生虫药物的来源:实验研究综述。
尽管现代人类和兽医医学取得了进步,但胃肠道寄生虫感染仍然是全世界(主要是发展中国家)的一个重大健康问题。越来越多的证据表明,这些寄生虫具有多重抗药性,而且目前可用的合成药物有副作用,这促使人们加大了对治疗寄生虫感染的替代药物的研究。在这种情况下,探索潜在的植物抗寄生虫药物(价格低廉且资源丰富)可能是一种很有前景的替代方法。本研究总结了不同药用植物及其成分对消化道寄生虫的体外/体内抗寄生虫药效。研究人员从 Google Scholar、Web of Science、PubMed 和 Scopus 上检索了 1990-2020 年间发表的文献。全球共有 32 个科的 68 种植物被评估为胃肠道寄生虫的抗寄生剂。大多数研究(70%)是在体外进行的。大多数植物来自豆科(53%,n = 18)。甲醇(37%,n = 35)是使用最多的溶剂。叶(22%,n = 16)是使用最多的植物部分,其次是种子和根茎(各占 12%,n = 9)。这些研究表明,中草药在发现防治寄生虫病的新药方面具有广阔的前景,而且这些植物的衍生物是药物合成和生物活性优化的有用结构。
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来源期刊
Pathogens and Global Health
Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY
CiteScore
6.00
自引率
0.00%
发文量
60
审稿时长
6-12 weeks
期刊介绍: Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.
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