Spatiotemporal insight into early pregnancy governed by immune-featured stromal cells.

IF 45.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2023-09-28 Epub Date: 2023-09-11 DOI:10.1016/j.cell.2023.08.020

Min Yang, Jennie Ong, Fanju Meng, Feixiang Zhang, Hui Shen, Kerstin Kitt, Tengfei Liu, Wei Tao, Peng Du

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引用次数: 3

Abstract

Endometrial decidualization connecting embryo implantation and placentation is transient but essential for successful pregnancy, which, however, is not systematically investigated. Here, we use a scStereo-seq technology to spatially visualize and define the dynamic functional decidual hubs assembled by distinct immune, endothelial, trophoblast, and decidual stromal cells (DSCs) in early pregnant mice. We unravel the DSC transdifferentiation trajectory and surprisingly discover a dual-featured type of immune-featured DSCs (iDSCs). We find that immature DSCs attract immune cells and induce decidual angiogenesis at the mesenchymal-epithelial transition hub during decidualization initiation. iDSCs enable immune cell recruitment and suppression, govern vascularization, and promote cytolysis at immune cell assembling and vascular hubs, respectively, to establish decidual homeostasis at a later stage. Interestingly, dysfunctional and spatially disordered iDSCs cause abnormal accumulation of immune cells in the vascular hub, which disrupts decidual hub specification and eventually leads to pregnancy complications in DBA/2-mated CBA/J mice.

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免疫基质细胞对早孕的时空洞察。

连接胚胎植入和胎盘形成的子宫内膜蜕膜化是短暂的，但对成功怀孕至关重要，然而，这一点尚未得到系统的研究。在这里，我们使用scStereo-seq技术在空间上可视化和定义早孕小鼠中由不同的免疫、内皮、滋养层和蜕膜基质细胞（DSC）组装的动态功能性蜕膜中枢。我们揭示了DSC的转分化轨迹，并出人意料地发现了一种双重特征类型的免疫特征DSC（iDSC）。我们发现，在蜕膜化起始过程中，未成熟的DSCs在间充质-上皮过渡中枢吸引免疫细胞并诱导蜕膜血管生成。iDSCs能够实现免疫细胞募集和抑制，控制血管形成，并分别促进免疫细胞组装和血管中枢的细胞溶解，以在后期建立蜕膜稳态。有趣的是，功能失调和空间紊乱的iDSCs会导致免疫细胞在血管中枢中异常积聚，从而破坏蜕膜中枢的规格，并最终导致DBA/2-甲基CBA/J小鼠的妊娠并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.