Study effect of MAPA-VIP on control of allergic asthma pathophysiology.

IF 1.4 4区医学 Q3 ALLERGY

Postepy Dermatologii I Alergologii Pub Date : 2023-08-01 DOI:10.5114/ada.2023.129458

Weihong Jia, Dongcai Yang

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Abstract

Introduction: Asthma is a pulmonary disease and its pathogenesis is involved with immune cells and related signalling pathways. Alpha-alumina is material for therapy applications and mucus adhesion promoting protein is cell-surface protein. Vasoactive intestinal peptide (VIP) exerts immunomodulation. Therefore, the drug delivery system and target binding molecule could be applicable for treatment of asthma.

Material and methods: VIP-MapA-α-alumina was administered to asthmatic mice. Then, eosinophil percentage, IgE, IL-4, IL-5, and IL-13 levels, GATA3, and MUC5AC gene expression, ROS and lung histopathology were studied.

Results: Eosinophil percentage, IgE, IL-4, IL-5, IL-13, and ROS levels, expression of GATA3 and MUC5AC genes, goblet cell hyperplasia, mucus hyper-production, perivascular and peribronchial inflammation were decreased in VIP and VIP-MapA treated groups and treatment with VIP-MapA has a stronger effect than VIP alone.

Conclusions: The delivery system of VIP carrying to the lung with the use of MapA as an adhesion molecule, could easily carry VIP and led to penetration of this component to the mucus and reach bronchial cells and present an effective, strong, and long-acting effect on therapy of asthma.

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MAPA-VIP对变应性哮喘病理生理控制作用的研究。

简介:哮喘是一种肺部疾病，其发病机制与免疫细胞及相关信号通路有关。α -氧化铝是用于治疗的材料，促进黏液粘附的蛋白是细胞表面蛋白。血管活性肠肽(VIP)具有免疫调节作用。因此，该给药系统和靶标结合分子可应用于哮喘的治疗。材料与方法:VIP-MapA-α-氧化铝灌胃哮喘小鼠。然后观察各组嗜酸性粒细胞百分比、IgE、IL-4、IL-5、IL-13水平、GATA3、MUC5AC基因表达、ROS及肺组织病理学变化。结果:VIP组和VIP- mapa组嗜酸性粒细胞百分比、IgE、IL-4、IL-5、IL-13、ROS水平、GATA3和MUC5AC基因表达、杯状细胞增生、粘液分泌增多、血管周围和支气管周围炎症均降低，且VIP- mapa组治疗效果强于VIP单独治疗。结论:利用MapA作为黏附分子的VIP携带至肺的递送系统，可以很容易携带VIP并使其渗透到黏液中到达支气管细胞，对哮喘的治疗具有有效、强效、长效的效果。

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