Genotype-guided dual antiplatelet therapy in cerebrovascular disease: assessing the risk and benefits for ethnic populations.

IF 1.8 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Expert Review of Cardiovascular Therapy Pub Date : 2023-07-01 Epub Date: 2023-08-13 DOI:10.1080/14779072.2023.2245754

Kasim Qureshi, Muhammad U Farooq, Philip B Gorelick

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Abstract

Introduction: Cerebrovascular disease is a leading cause of morbidity and mortality in the world and antiplatelet therapy is a main pharmacologic means of secondary prevention. Clinical information has accumulated about benefit of dual antiplatelet therapy in certain clinical scenarios, genetic causes of antiplatelet resistance and its effect on clinical outcomes, and ethnic and geographic distributions of genetic polymorphisms.

Areas covered: This review covers literature related to the pharmacogenomics of antiplatelet agents with a focus on ethnic variability, antiplatelet resistance, and dual antiplatelet therapy in cerebrovascular disease.

Expert opinion: Selecting patients for dual antiplatelet therapy and specific agents require consideration of multiple factors. Ethnic factors should be considered in certain circumstances, but additional research is needed to determine the generalizability of the findings.

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基因型引导的双抗血小板治疗脑血管疾病：评估种族人群的风险和益处。

引言：脑血管病是世界上发病和死亡的主要原因，抗血小板治疗是二级预防的主要药物手段。已经积累了关于双重抗血小板治疗在某些临床情况下的益处、抗血小板耐药性的遗传原因及其对临床结果的影响以及遗传多态性的种族和地理分布的临床信息。涵盖领域：这篇综述涵盖了抗血小板药物的药物基因组学相关文献，重点是种族变异性、抗血小板耐药性和脑血管疾病的双重抗血小板治疗。专家意见：选择双重抗血小板治疗和特效药的患者需要考虑多个因素。在某些情况下应该考虑种族因素，但还需要进一步的研究来确定研究结果的可推广性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Cardiovascular Therapy CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

3.70

自引率

0.00%

发文量

期刊介绍： Expert Review of Cardiovascular Therapy (ISSN 1477-9072) provides expert reviews on the clinical applications of new medicines, therapeutic agents and diagnostics in cardiovascular disease. Coverage includes drug therapy, heart disease, vascular disorders, hypertension, cholesterol in cardiovascular disease, heart disease, stroke, heart failure and cardiovascular surgery. The Expert Review format is unique. Each review provides a complete overview of current thinking in a key area of research or clinical practice.