Comparative proteomics of saliva of healthy and gingivitis individuals from Rio de Janeiro.

IF 2.5 4区生物学 Q3 BIOCHEMICAL RESEARCH METHODS

PROTEOMICS – Clinical Applications Pub Date : 2023-09-01 Epub Date: 2023-02-17 DOI:10.1002/prca.202200098

Carlos Vinicius Ferreira da Silva, Youssef Bacila Sade, Sandra Mara Naressi Scapin, Carina M da Silva-Boghossian, Eidy de Oliveira Santos

引用次数: 0

Abstract

In this work, we identified human and bacterial proteomes in the saliva from volunteers with gingivitis or healthy.

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里约热内卢健康人和牙龈炎患者唾液的比较蛋白质组学。

目的：在这项工作中，我们在患有牙龈炎或健康的志愿者的唾液中鉴定了人类和细菌蛋白质组。实验设计：报告的人群包括18名志愿者（6名患有牙龈炎，12名健康对照）。使用定量质谱法进行蛋白质组学表征。结果：唾液中共鉴定出74种人类蛋白质和116种细菌蛋白质。人类蛋白质组中被修饰的主要功能类别是免疫反应，其次是转运和蛋白酶抑制。在细菌蛋白质组中，大多数鉴定的蛋白质来自梭杆菌门，其次是衣原体和螺旋体。结论和临床相关性：我们观察到两组之间的数据存在统计学上相关的差异。影响病例组和对照组之间变异的15种最重要的人类蛋白质包括胱抑素S、α-淀粉酶、乳转铁蛋白和负延伸因子E。与红色和橙色复合体相关的有核细胞与牙周病的发生密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PROTEOMICS – Clinical Applications 医学-生化研究方法

CiteScore

5.20

自引率

5.00%

发文量

审稿时长

1 months

期刊介绍： PROTEOMICS - Clinical Applications has developed into a key source of information in the field of applying proteomics to the study of human disease and translation to the clinic. With 12 issues per year, the journal will publish papers in all relevant areas including: -basic proteomic research designed to further understand the molecular mechanisms underlying dysfunction in human disease -the results of proteomic studies dedicated to the discovery and validation of diagnostic and prognostic disease biomarkers -the use of proteomics for the discovery of novel drug targets -the application of proteomics in the drug development pipeline -the use of proteomics as a component of clinical trials.