Obesity, cancer and acetyl-CoA metabolism

Abstract

As rates of obesity soar in the Unites States and around the world, cancer attributed to obesity has emerged as a major threat to public health. The link between obesity and cancer can be attributed in part to the state of chronic inflammation, which develops in obesity. Acetyl-CoA production and protein acetylation patterns are highly sensitive to metabolic state and are significantly altered in obesity. In this article, we explore the potential role of nutrient-sensitive lysine acetylation in regulating inflammatory processes in obesity-linked cancer.