The Japanese nationwide cohort data of proton beam therapy for liver oligometastasis in esophagogastric cancer patients.

IF 1.9 4区 医学 Q2 BIOLOGY
Hisashi Yamaguchi, Nobuyoshi Fukumitsu, Haruko Numajiri, Hiroyuki Ogino, Norio Katoh, Tomoaki Okimoto, Motohisa Suzuki, Hideyuki Sakurai
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引用次数: 0

Abstract

A nationwide multicenter cohort study on particle therapy was launched by the Japanese Society for Radiation Oncology in Japan in May 2016. We analyzed the outcome of proton beam therapy (PBT) for liver oligometastasis of esophagogastric cancers. Cases in which PBT was performed at all PBT facilities in Japan between May 2016 and February 2019 were enrolled. The patients were selected based on the following criteria: controlled primary cancer, liver recurrence without extrahepatic tumors and no more than three liver lesions. Twenty-two males and two females with a median age of 69 (range, 52-80) years and 35 lesions were included. This study included 6 patients with esophageal and 18 patients with gastric cancer. The median lesion size, fraction size and biological effective dose (BED)10 were 32 (7-104) mm, 3.8 gray (relative biological effect)/fractions (Gy (RBE)/fr) (2-8 Gy (RBE)/fr) and 96.9 (88.8-115.2) Gy, respectively. The median follow-up period was 18 (4-47) months. The 1-, 2- and 3-year overall survival (OS) rates were 75, 51.8 and 45.3%, respectively, and the median OS was 25.3 months. The 1-, 2- and 3-year cumulative local recurrence (LR) rates were 3, 6 and 6%, respectively. Patients' age (P < 0.01), performance status (P = 0.017) and tumor size (P = 0.024) were significant OS-related factors. No Grade 3 or higher adverse events (AEs) were observed. Owing to the low incidence of AEs and the low LR cumulative incidence, PBT is a feasible option for liver oligometastasis of esophagogastric cancers.

质子束治疗食管胃癌患者肝少转移的日本全国队列数据。
2016年5月,日本放射肿瘤学会(Japanese Society for Radiation Oncology)在日本发起了一项全国性的多中心队列研究。我们分析了质子束治疗(PBT)治疗食管胃癌肝少转移的结果。纳入了2016年5月至2019年2月期间在日本所有PBT机构进行PBT的病例。患者的选择标准为:原发癌控制,肝脏复发无肝外肿瘤,肝脏病变不超过3个。22名男性和2名女性,中位年龄为69岁(52-80岁),35个病变。本研究纳入6例食管癌患者和18例胃癌患者。中位病灶大小、分数大小和生物有效剂量(BED)10分别为32 (7-104)mm、3.8 gray(相对生物效应)/分数(Gy (RBE)/fr) (2-8 Gy (RBE)/fr)和96.9 (88.8-115.2)Gy。中位随访期为18(4-47)个月。1年、2年和3年总生存率(OS)分别为75,51.8和45.3%,中位OS为25.3个月。1年、2年和3年累积局部复发率分别为3.6%和6%。患者年龄(P
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来源期刊
CiteScore
3.60
自引率
5.00%
发文量
86
审稿时长
4-8 weeks
期刊介绍: The Journal of Radiation Research (JRR) is an official journal of The Japanese Radiation Research Society (JRRS), and the Japanese Society for Radiation Oncology (JASTRO). Since its launch in 1960 as the official journal of the JRRS, the journal has published scientific articles in radiation science in biology, chemistry, physics, epidemiology, and environmental sciences. JRR broadened its scope to include oncology in 2009, when JASTRO partnered with the JRRS to publish the journal. Articles considered fall into two broad categories: Oncology & Medicine - including all aspects of research with patients that impacts on the treatment of cancer using radiation. Papers which cover related radiation therapies, radiation dosimetry, and those describing the basis for treatment methods including techniques, are also welcomed. Clinical case reports are not acceptable. Radiation Research - basic science studies of radiation effects on livings in the area of physics, chemistry, biology, epidemiology and environmental sciences. Please be advised that JRR does not accept any papers of pure physics or chemistry. The journal is bimonthly, and is edited and published by the JRR Editorial Committee.
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