PCF Based Four-Channel SPR Biosensor With Wide Sensing Range

IF 3.7 4区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

IEEE Transactions on NanoBioscience Pub Date : 2023-09-04 DOI:10.1109/TNB.2023.3311611

Md. Shahedul Hasan;Md. Anas Ebna Kalam;Mohammad Faisal

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引用次数: 0

Abstract

In this article, we have demonstrated a highly sensitive four-channel photonic crystal fiber (PCF) based surface plasmon resonance (SPR) biosensor which can detect four different analytes simultaneously. To ease practical implementation, four analyte sensing layers and plasmonic materials such as gold (Au) and gold (Au) with Tantalum Pentoxide (Ta2O5) are placed on the exterior of the four arms of the square shaped structure. The sensor’s structure consists of only nine circular air holes, making it simple and easy to fabricate using currently available technologies. Finite element method (FEM) based numerical analysis is used to evaluate the sensing performance of the proposed sensor. With optimum structure parameters, the sensor achieves maximum wavelength sensitivity of 11000, 25000, 11000 and 25000 nm/RIU for Channel-1, Channel-2, Channel-3, and Channel-4 respectively. It shows maximum amplitude sensitivity of 803.732, 709.171, 803.827, 709.146 RIU

$^{-{1}}$

for Channel 1, 2, 3, and 4 respectively. It also shows maximum FOM of 232.55, 352.36, 231.57, 352.36 RIU

$^{-{1}}$

in Ch-1, Ch-2, Ch-3 and Ch-4 respectively. Moreover, the proposed sensor shows a wide range of refractive index sensing capability from 1.30 to 1.41. Due to multi-analyte detection capability, large sensing range, and excellent sensitivity the proposed sensor unfolds unrivalled capacity of detecting chemicals, carcinogenic agents, biomolecules, and other analytes.

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传感范围广的基于 PCF 的四通道 SPR 生物传感器

本文展示了一种基于光子晶体光纤（PCF）的高灵敏度四通道表面等离子体共振（SPR）生物传感器，可同时检测四种不同的分析物。为了便于实际应用，在方形结构的四个臂的外部放置了四个分析物传感层和等离子材料，如金（Au）和金（Au）与五氧化二钽（Ta2O5）。该传感器的结构仅由九个圆形气孔组成，因此利用现有技术制造起来既简单又容易。基于有限元法（FEM）的数值分析用于评估拟议传感器的传感性能。在结构参数最优化的情况下，传感器通道-1、通道-2、通道-3 和通道-4 的最大波长灵敏度分别为 11000、25000、11000 和 25000 nm/RIU。通道 1、通道 2、通道 3 和通道 4 的最大振幅灵敏度分别为 803.732、709.171、803.827 和 709.146 RIU-1。它还显示，通道 1、通道 2、通道 3 和通道 4 的最大 FOM 分别为 232.55、352.36、231.57、352.36 RIU-1。此外，所提出的传感器还具有从 1.30 到 1.41 的广泛折射率感应能力。由于具有多种分析物的检测能力、较大的感应范围和出色的灵敏度，该传感器在检测化学物质、致癌物质、生物大分子和其他分析物方面具有无与伦比的能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IEEE Transactions on NanoBioscience 工程技术-纳米科技

CiteScore

7.00

自引率

5.10%

发文量

197

审稿时长

>12 weeks

期刊介绍： The IEEE Transactions on NanoBioscience reports on original, innovative and interdisciplinary work on all aspects of molecular systems, cellular systems, and tissues (including molecular electronics). Topics covered in the journal focus on a broad spectrum of aspects, both on foundations and on applications. Specifically, methods and techniques, experimental aspects, design and implementation, instrumentation and laboratory equipment, clinical aspects, hardware and software data acquisition and analysis and computer based modelling are covered (based on traditional or high performance computing - parallel computers or computer networks).