Objective monitoring of laser tattoo removal in human volunteers using an innovative optical technique: A proof of principle

IF 2.2 3区医学 Q2 DERMATOLOGY

Lasers in Surgery and Medicine Pub Date : 2023-09-01 DOI:10.1002/lsm.23720

Neža Golmajer Zima MSc, Nina Verdel PhD, Matjaž Lukač PhD, Boris Majaron PhD

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引用次数: 0

Abstract

Objectives

Assess the suitability of the technique for objective monitoring of laser tattoo removal by an extended treatment protocol.

Materials and Methods

One half of the tattoo in the first volunteer was treated with nanosecond and the other half with picosecond laser pulses at 1064 nm. In the second subject, four test areas were treated repeatedly using different radiant exposures from 1.5 to 6 J/cm². Measurements of diffuse reflectance spectra and photothermal radiometric transients were performed 4–20 weeks after each treatment session. Inverse Monte Carlo analysis based on a three-layer model of tattooed skin was applied to assess the tattoo characteristics and analyze their changes.

Results

The results clearly indicate a gradual reduction of the ink content and an increase of the subsurface depth of the tattoo layer with all treatments at a radiant exposure of 3 J/cm² or higher. The observed dependences on laser pulse duration, radiant exposure, and a number of treatments are in excellent agreement with visual fading of the tattoo.

Conclusions

The presented methodology enables noninvasive characterization of tattoos in human skin and objective monitoring of the laser removal treatment.

Abstract Image

查看原文本刊更多论文

使用创新光学技术对人类志愿者激光纹身去除进行客观监测：原理验证。

目的：通过扩展治疗方案评估该技术对激光纹身去除的客观监测的适用性。材料和方法：第一名志愿者的一半纹身用纳秒处理，另一半用1064皮秒激光脉冲处理 nm。在第二个受试者中，使用1.5至6的不同辐射暴露对四个测试区域进行重复治疗 J/cm2。在每次治疗后4-20周进行漫反射光谱和光热辐射瞬态的测量。应用基于纹身皮肤三层模型的逆蒙特卡罗分析来评估纹身特征并分析其变化。结果：结果清楚地表明，在辐射暴露3 J/cm2或更高。观察到的对激光脉冲持续时间、辐射暴露和多种处理的依赖性与纹身的视觉褪色非常一致。结论：所提出的方法能够对人类皮肤上的纹身进行无创表征，并对激光去除治疗进行客观监测。

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来源期刊

Lasers in Surgery and Medicine 医学-外科

CiteScore

5.40

自引率

12.50%

发文量

119

审稿时长

1 months

期刊介绍： Lasers in Surgery and Medicine publishes the highest quality research and clinical manuscripts in areas relating to the use of lasers in medicine and biology. The journal publishes basic and clinical studies on the therapeutic and diagnostic use of lasers in all the surgical and medical specialties. Contributions regarding clinical trials, new therapeutic techniques or instrumentation, laser biophysics and bioengineering, photobiology and photochemistry, outcomes research, cost-effectiveness, and other aspects of biomedicine are welcome. Using a process of rigorous yet rapid review of submitted manuscripts, findings of high scientific and medical interest are published with a minimum delay.

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