Differential symptom weighting in estimating empirical thresholds for underlying PTSD severity: Toward a “platinum” standard for diagnosis?

IF 2.4 3区 医学 Q2 PSYCHIATRY
Antonio A. Morgan-López, Lissette M. Saavedra, Denise A. Hien, Sonya B. Norman, Skye S. Fitzpatrick, Ai Ye, Therese K. Killeen, Lesia M. Ruglass, Shannon M. Blakey, Sudie E. Back
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引用次数: 1

Abstract

Objective

Symptom counts as the basis for Post-Traumatic Stress Disorder (PTSD) diagnoses in the DSM presume each symptom is equally reflective of underlying disorder severity. However, the “equal weight” assumption fails to fit PTSD symptom data when tested. The present study developed an enhanced PTSD diagnosis based on (a) a conventional PTSD diagnosis from a clinical interview and (b) an empirical classification of full PTSD that reflected the relative clinical weights of each symptom.

Method

Baseline structured interview data from Project Harmony (N = 2658) was used. An enhanced diagnosis for full PTSD was estimated using an empirical threshold from moderated nonlinear factor analysis (MNLFA) latent PTSD scale scores, in combination with a full conventional PTSD diagnosis based on interview data.

Results

One in 4 patients in the sample had a PTSD diagnosis that was inconsistent with their empirical PTSD grouping, such that the enhanced diagnostic standard reduced the diagnostic discrepancy rate by 20%. Veterans, and in particular female Veterans, were at greatest odds for discrepancy between their underlying PTSD severity and DSM diagnosis.

Conclusion

Psychometric methodologies that differentially weight symptoms can complement DSM criteria and may serve as a platform for symptom prioritization for diagnoses in future editions of DSM.

Abstract Image

评估潜在创伤后应激障碍严重程度的经验阈值的差异症状加权:迈向诊断的“白金”标准?
客观症状作为DSM中创伤后应激障碍(PTSD)诊断的基础,假设每种症状都同样反映了潜在障碍的严重程度。然而,“同等权重”假设在测试时不符合PTSD症状数据。本研究基于(a)来自临床访谈的常规PTSD诊断和(b)反映每种症状的相对临床权重的完整PTSD的经验分类,开发了一种增强的PTSD诊断。方法采用Harmony项目的基线结构化访谈数据(N = 2658)。利用调节非线性因子分析(MNLFA)潜在PTSD量表得分的经验阈值,结合基于访谈数据的完全常规PTSD诊断,估计增强诊断为完全PTSD。结果样本中每4例患者中就有1例的PTSD诊断与其经验PTSD分组不一致,提高后的诊断标准使诊断差异率降低了20%。退伍军人,尤其是女性退伍军人,其潜在的创伤后应激障碍严重程度与DSM诊断之间的差异最大。结论不同体重症状的心理测量方法可作为DSM标准的补充,并可作为未来DSM版本中诊断症状优先级的平台。
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来源期刊
CiteScore
5.20
自引率
6.50%
发文量
48
审稿时长
>12 weeks
期刊介绍: The International Journal of Methods in Psychiatric Research (MPR) publishes high-standard original research of a technical, methodological, experimental and clinical nature, contributing to the theory, methodology, practice and evaluation of mental and behavioural disorders. The journal targets in particular detailed methodological and design papers from major national and international multicentre studies. There is a close working relationship with the US National Institute of Mental Health, the World Health Organisation (WHO) Diagnostic Instruments Committees, as well as several other European and international organisations. MPR aims to publish rapidly articles of highest methodological quality in such areas as epidemiology, biostatistics, generics, psychopharmacology, psychology and the neurosciences. Articles informing about innovative and critical methodological, statistical and clinical issues, including nosology, can be submitted as regular papers and brief reports. Reviews are only occasionally accepted. MPR seeks to monitor, discuss, influence and improve the standards of mental health and behavioral neuroscience research by providing a platform for rapid publication of outstanding contributions. As a quarterly journal MPR is a major source of information and ideas and is an important medium for students, clinicians and researchers in psychiatry, clinical psychology, epidemiology and the allied disciplines in the mental health field.
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