The efficacy of trastuzumab-deruxtecan for the treatment of patients with advanced HER2-low breast cancer.

IF 2.9 3区 医学 Q2 ONCOLOGY
Expert Review of Anticancer Therapy Pub Date : 2024-11-01 Epub Date: 2023-09-12 DOI:10.1080/14737140.2023.2171993
Ilana Schlam, Sara M Tolaney, Paolo Tarantino
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引用次数: 0

Abstract

Introduction: Until recently, the available human receptor epidermal growth factor 2 (HER2) targeted agents were ineffective for treating patients with HER2-low expressing breast cancer (defined as immunohistochemical expression of 1+ or 2+ without amplification). The development of novel and potent HER2-directed antibody-drug conjugates, affective at treating HER2-low expressing breast cancers, have changed the way we think about HER2-low expression and expanded the treatment options for many patients with advanced disease.

Areas covered: In this review, we summarize the current management of HER2-low breast cancer and commonly encountered challenges such as treatment sequencing and toxicity management.

Expert opinion: trastuzumab deruxtecan (T-DXd) is a treatment option for patients with advanced, HER2-low breast cancer, irrespective of the hormone receptor status. The current optimal place in treatment algorithms is after the first line of chemotherapy, both in HR-positive and triple-negative breast cancer; however, other agents are available in this setting and risks and benefits for each should be considered in shared decision making. Up to 10-15% of patients receiving T-DXd develop interstitial lung disease. Patient and clinician education are key to safely implement T-DXd in clinical practice.

曲妥珠单抗-德鲁司坦治疗晚期 HER2 低乳腺癌患者的疗效。
简介直到最近,现有的人类受体表皮生长因子 2(HER2)靶向药物对治疗 HER2 低表达乳腺癌患者(定义为免疫组化表达为 1+ 或 2+,无扩增)效果不佳。新型强效 HER2 靶向抗体-药物共轭物的开发可有效治疗 HER2 低表达乳腺癌,改变了我们对 HER2 低表达的看法,为许多晚期患者提供了更多的治疗选择:专家观点:无论激素受体状态如何,曲妥珠单抗德鲁司坦(T-DXd)都是晚期HER2低表达乳腺癌患者的治疗选择。目前,无论是HR 阳性还是三阴性乳腺癌,其最佳治疗方案都是在一线化疗之后;不过,在这种情况下也可使用其他药物,在共同决策时应考虑每种药物的风险和益处。在接受 T-DXd 治疗的患者中,高达 10-15% 的患者会出现间质性肺病。在临床实践中安全使用 T-DXd 的关键是对患者和临床医生进行教育。
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来源期刊
CiteScore
5.10
自引率
3.00%
发文量
100
审稿时长
4-8 weeks
期刊介绍: Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches. Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.
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