Direct brain involvement of Takayasu arteritis treated with rituximab and infliximab: a case report.

Seondeuk Kim, Seon-Jae Ahn, Han Sang Lee, Woo-Jin Lee, Jangsup Moon, Jin Kyun Park, Kon Chu
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引用次数: 1

Abstract

Takayasu arteritis (TAK) is a systemic vasculitis involving large arteries. Reports of direct central nervous system (CNS) involvement in TAK are extremely rare in the literature. In addition, treatment for direct involvement has not been reported. Herein, we describe a case of encephalitis in a TAK patient who presented with fever and headache at the first attack, then cognitive impairment at the second attack. The patient improved with rituximab and especially infliximab. These findings indicate the usefulness of rituximab and infliximab to treat the direct CNS manifestations in TAK.

Abstract Image

Abstract Image

利妥昔单抗联合英夫利昔单抗治疗高须动脉炎直接脑受累1例。
高须动脉炎(taku arteritis, TAK)是一种累及大动脉的系统性血管炎。关于中枢神经系统(CNS)直接参与TAK的报道在文献中极为罕见。此外,对直接参与的治疗还没有报道。在此,我们描述了一例脑炎在TAK患者谁表现为发烧和头痛在第一次发作,然后认知障碍在第二次发作。患者使用利妥昔单抗,尤其是英夫利昔单抗后病情好转。这些发现表明利妥昔单抗和英夫利昔单抗治疗TAK的直接中枢神经系统表现是有用的。
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