Ke Zhu, Zhong Zheng, Ya-Yun Zhang, Zhuo-Yao Li, Ai-Fang Zhou, Cai-Wei Hu, Bing Shu, Long-Yun Zhou, Qi Shi, Yong-Jun Wang, Min Yao, Xue-Jun Cui
{"title":"A comprehensive and systematic review of the potential neuroprotective effect of quercetin in rat models of spinal cord injury.","authors":"Ke Zhu, Zhong Zheng, Ya-Yun Zhang, Zhuo-Yao Li, Ai-Fang Zhou, Cai-Wei Hu, Bing Shu, Long-Yun Zhou, Qi Shi, Yong-Jun Wang, Min Yao, Xue-Jun Cui","doi":"10.1080/1028415X.2023.2257425","DOIUrl":null,"url":null,"abstract":"<p><strong>Context: </strong>Spinal cord injury (SCI) is a potentially fatal neurological disease with severe complications and a high disability rate. An increasing number of animal experimental studies support the therapeutic effect of quercetin, which is a natural anti-inflammatory and antioxidant bioflavonoid.</p><p><strong>Objective: </strong>This paper reviewed the therapeutic effect of quercetin on a rat SCI model and summarized the relevant mechanistic research.</p><p><strong>Data sources: </strong>PubMed, EMBASE, Web of Science, Science Direct, WanFang Data, SinoMed databases, the China National Knowledge Infrastructure, and the Vip Journal Integration Platform were searched from their inception to April 2023 for animal experiments applying quercetin to treat SCI.</p><p><strong>Study selection: </strong>Based on the PICOS criteria, a total of 18 eligible studies were included, of which 14 were high quality.</p><p><strong>Results: </strong>In this study, there was a gradual increase in effect based on the Basso, Beattie, and Bresnahan (BBB) score after three days (<i>p </i>< 0.0001). Furthermore, gender differences also appeared in the efficacy of quercetin; males performed better than females (<i>p</i> = 0.008). Quercetin was also associated with improved inclined plane test score (<i>p</i> = 0.008). In terms of biochemical indicators, meta-analysis showed that MDA (<i>p</i> < 0.0001) and MPO (<i>p</i> = 0.0002) were significantly reduced after quercetin administration compared with the control group, and SOD levels were increased (<i>p</i> = 0.004). Mechanistically, quercetin facilitates the inhibition of oxidative stress, inflammation, autophagy and apoptosis that occur after SCI.</p><p><strong>Conclusions: </strong>Generally, this systematic review suggests that quercetin has a neuroprotective effect on SCI.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"857-869"},"PeriodicalIF":3.6000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutritional Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/1028415X.2023.2257425","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/9/10 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Context: Spinal cord injury (SCI) is a potentially fatal neurological disease with severe complications and a high disability rate. An increasing number of animal experimental studies support the therapeutic effect of quercetin, which is a natural anti-inflammatory and antioxidant bioflavonoid.
Objective: This paper reviewed the therapeutic effect of quercetin on a rat SCI model and summarized the relevant mechanistic research.
Data sources: PubMed, EMBASE, Web of Science, Science Direct, WanFang Data, SinoMed databases, the China National Knowledge Infrastructure, and the Vip Journal Integration Platform were searched from their inception to April 2023 for animal experiments applying quercetin to treat SCI.
Study selection: Based on the PICOS criteria, a total of 18 eligible studies were included, of which 14 were high quality.
Results: In this study, there was a gradual increase in effect based on the Basso, Beattie, and Bresnahan (BBB) score after three days (p < 0.0001). Furthermore, gender differences also appeared in the efficacy of quercetin; males performed better than females (p = 0.008). Quercetin was also associated with improved inclined plane test score (p = 0.008). In terms of biochemical indicators, meta-analysis showed that MDA (p < 0.0001) and MPO (p = 0.0002) were significantly reduced after quercetin administration compared with the control group, and SOD levels were increased (p = 0.004). Mechanistically, quercetin facilitates the inhibition of oxidative stress, inflammation, autophagy and apoptosis that occur after SCI.
Conclusions: Generally, this systematic review suggests that quercetin has a neuroprotective effect on SCI.
期刊介绍：
Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
