Pharmacologically Treated Anxiety and Depression in People Diagnosed with von Willebrand Disease: Matched Cohort Study.

IF 2.1 Q3 HEMATOLOGY
Katrina Wilcox Hagberg, Susan Jick, Gülden Özen, Ping Du
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Abstract

Background: People diagnosed with von Willebrand disease (VWD) have reduced quality of life versus the general population, and there is limited evidence of increased rates of anxiety and/or depression among people diagnosed with VWD.

Aim: To understand the association between VWD and mental health outcomes.

Design and setting: A retrospective cohort study was conducted using the UK Clinical Practice Research Datalink (CPRD) GOLD database (1988-2016).

Methods: People diagnosed with VWD were matched 1:10 to randomly selected people in the database without VWD based on sex, birth year ±2 years, CPRD record start year ±2 years, and general practice attended. Individuals were followed from VWD diagnosis or match date to censoring (first event date, CPRD end date, or death). Treated anxiety and treated depression were identified by a diagnostic Read Code and a prescription for anxiety/depression medication recorded within 90 days of each other, after VWD diagnosis/match date.

Results: Treated anxiety was recorded in 89 of 1119 (8.0%) people diagnosed with VWD and 624 of 10,423 (6.0%) without VWD (age- and sex-adjusted incidence rate ratio [IRR], 1.37; 95% confidence interval [CI], 1.10-1.71). Treated depression was recorded in 119 of 1083 (11.0%) people diagnosed with VWD and 846 of 9845 (8.6%) without VWD (adjusted IRR, 1.35; 95% CI, 1.11-1.63). Females aged 20-39 and 0-19 years were at greatest risk for treated anxiety and treated depression, respectively.

Conclusion: Higher rates of treated anxiety and depression were observed among people diagnosed with versus without VWD, predominantly in young females.

Abstract Image

Abstract Image

血管性血友病患者的药物治疗焦虑和抑郁:匹配队列研究
背景:与一般人群相比,被诊断为血管性血友病(VWD)的患者生活质量下降,并且有有限的证据表明VWD患者的焦虑和/或抑郁发生率增加。目的:了解VWD与心理健康结果之间的关系。设计和背景:使用英国临床实践研究数据链(CPRD) GOLD数据库(1988-2016)进行了一项回顾性队列研究。方法:根据性别、出生年份±2年、CPRD记录开始年份±2年以及全科就诊情况,将诊断为VWD的患者与数据库中随机选择的无VWD人群进行1:10匹配。个体从VWD诊断或匹配日期到审查(首次事件日期,CPRD结束日期或死亡)进行随访。在VWD诊断/匹配日期后90天内,通过诊断读取代码和焦虑/抑郁药物处方来识别治疗焦虑症和治疗抑郁症。结果:确诊为VWD的1119人中有89人(8.0%)焦虑得到治疗,未确诊为VWD的10423人中有624人(6.0%)焦虑得到治疗(年龄和性别校正发病率比[IRR], 1.37;95%置信区间[CI], 1.10-1.71)。1083名确诊为VWD的患者中有119人(11.0%)接受了抑郁症治疗,9845名未确诊为VWD的患者中有846人(8.6%)接受了抑郁症治疗(调整IRR, 1.35;95% ci, 1.11-1.63)。20-39岁和0-19岁的女性分别出现焦虑治疗和抑郁治疗的风险最高。结论:在诊断为VWD的人群中,治疗焦虑症和抑郁症的比例高于未诊断为VWD的人群,主要发生在年轻女性中。
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来源期刊
CiteScore
3.50
自引率
0.00%
发文量
94
审稿时长
16 weeks
期刊介绍: The Journal of Blood Medicine is an international, peer-reviewed, open access, online journal publishing laboratory, experimental and clinical aspects of all topics pertaining to blood based medicine including but not limited to: Transfusion Medicine (blood components, stem cell transplantation, apheresis, gene based therapeutics), Blood collection, Donor issues, Transmittable diseases, and Blood banking logistics, Immunohematology, Artificial and alternative blood based therapeutics, Hematology including disorders/pathology related to leukocytes/immunology, red cells, platelets and hemostasis, Biotechnology/nanotechnology of blood related medicine, Legal aspects of blood medicine, Historical perspectives. Original research, short reports, reviews, case reports and commentaries are invited.
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