Frailty and comorbidities among young adult cancer survivors enrolled in an mHealth physical activity intervention trial.

IF 3.1 2区医学 Q2 ONCOLOGY

Journal of Cancer Survivorship Pub Date : 2025-02-01 Epub Date: 2023-08-23 DOI:10.1007/s11764-023-01448-4

Erin M Coffman, Andrew B Smitherman, Erik A Willis, Dianne S Ward, Deborah F Tate, Carmina G Valle

{"title":"Frailty and comorbidities among young adult cancer survivors enrolled in an mHealth physical activity intervention trial.","authors":"Erin M Coffman, Andrew B Smitherman, Erik A Willis, Dianne S Ward, Deborah F Tate, Carmina G Valle","doi":"10.1007/s11764-023-01448-4","DOIUrl":null,"url":null,"abstract":"Purpose: The physical frailty phenotype identifies individuals at risk for adverse health outcomes but has rarely been assessed among young adult cancer survivors (YACS). This study describes frailty status among YACS participating in a physical activity (PA) intervention trial.Methods: YACS were categorized at baseline using the 5-item FRAIL scale: fatigue; weight loss; illness; ambulation; resistance. Chi-square tests compared frailty and non-cancer comorbidities by characteristics. Prevalence rates (PRs) for the independent associations between characteristics, frailty, and comorbidities were estimated using modified Poisson regression models.Results: Among 280 YACS (82% female; mean (M) age = 33.4 ± 4.8 years, M=3.7 ± 2.4 years post-diagnosis), 11% frail, 17% prefrail; the most frequent criteria were fatigue (41%), resistance (38%), and ambulation (14%). Compared to BMI < 25, higher BMI was associated with increased likelihood of frailty (BMI 25-30, PR: 2.40, 95% CI: 1.38-4.17; BMI > 30, PR: 2.95, 95% CI: 1.71-5.08). Compared to 0, ≥ 30 min/week of moderate-to-vigorous PA was associated with reduced frailty (PR: 0.39, 95% CI: 0.25-0.60). Most YACS (55%) reported ≥ 1 comorbidity, most frequently depression (38%), thyroid condition (19%), and hypertension (10%). Comorbidities were more common for women (59% vs. 37%) and current/former smokers (PR: 1.71, 95% CI: 1.29-2.28).Conclusion: Prevalence of frailty and comorbidities in this sample was similar to other YACS cohorts and older adults without cancer and may be an indicator of accelerated aging and increased risk for poor outcomes.Implications for cancer survivors: Assessment of frailty may help identify YACS at increased risk for adverse health outcomes.","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":"54-65"},"PeriodicalIF":3.1000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10884352/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cancer Survivorship","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11764-023-01448-4","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/8/23 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: The physical frailty phenotype identifies individuals at risk for adverse health outcomes but has rarely been assessed among young adult cancer survivors (YACS). This study describes frailty status among YACS participating in a physical activity (PA) intervention trial.

Methods: YACS were categorized at baseline using the 5-item FRAIL scale: fatigue; weight loss; illness; ambulation; resistance. Chi-square tests compared frailty and non-cancer comorbidities by characteristics. Prevalence rates (PRs) for the independent associations between characteristics, frailty, and comorbidities were estimated using modified Poisson regression models.

Results: Among 280 YACS (82% female; mean (M) age = 33.4 ± 4.8 years, M=3.7 ± 2.4 years post-diagnosis), 11% frail, 17% prefrail; the most frequent criteria were fatigue (41%), resistance (38%), and ambulation (14%). Compared to BMI < 25, higher BMI was associated with increased likelihood of frailty (BMI 25-30, PR: 2.40, 95% CI: 1.38-4.17; BMI > 30, PR: 2.95, 95% CI: 1.71-5.08). Compared to 0, ≥ 30 min/week of moderate-to-vigorous PA was associated with reduced frailty (PR: 0.39, 95% CI: 0.25-0.60). Most YACS (55%) reported ≥ 1 comorbidity, most frequently depression (38%), thyroid condition (19%), and hypertension (10%). Comorbidities were more common for women (59% vs. 37%) and current/former smokers (PR: 1.71, 95% CI: 1.29-2.28).

Conclusion: Prevalence of frailty and comorbidities in this sample was similar to other YACS cohorts and older adults without cancer and may be an indicator of accelerated aging and increased risk for poor outcomes.

Implications for cancer survivors: Assessment of frailty may help identify YACS at increased risk for adverse health outcomes.

查看原文本刊更多论文

参加移动医疗体育活动干预试验的年轻成年癌症幸存者的虚弱和合并症。

目的：体质虚弱表型可识别有不良健康后果风险的个体，但很少在年轻的成年癌症幸存者（YACS）中进行评估。本研究描述了参加体育锻炼（PA）干预试验的青年癌症幸存者的虚弱状况：方法：在基线时使用 5 项 FRAIL 量表对 YACS 进行分类：疲劳、体重减轻、疾病、行动不便、抵抗力。对不同特征的虚弱和非癌症合并症进行了卡方检验。使用修正的泊松回归模型估算了特征、虚弱和合并症之间独立关联的患病率（PRs）：在 280 名 YACS（82% 为女性；平均年龄（M）= 33.4 ± 4.8 岁，诊断后平均年龄（M）= 3.7 ± 2.4 岁）中，11% 的人体弱，17% 的人体弱前；最常见的标准是疲劳（41%）、抵抗力（38%）和行动不便（14%）。与 BMI 30 相比，PR：2.95，95% CI：1.71-5.08）。与 0 相比，每周≥ 30 分钟的中度至剧烈活动与虚弱程度的降低有关（PR：0.39，95% CI：0.25-0.60）。大多数 YACS（55%）报告了≥一种合并症，最常见的是抑郁症（38%）、甲状腺疾病（19%）和高血压（10%）。合并症在女性（59% 对 37%）和目前/曾经吸烟者中更为常见（PR：1.71，95% CI：1.29-2.28）：该样本中虚弱和合并症的发生率与其他 YACS 群体和未患癌症的老年人相似，可能是加速衰老和增加不良后果风险的指标：对癌症幸存者的启示：对虚弱程度进行评估有助于识别面临不良健康后果风险增加的 YACS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Cancer Survivorship ONCOLOGY-

CiteScore

7.00

自引率

10.80%

发文量

149

审稿时长

>12 weeks

期刊介绍： Cancer survivorship is a worldwide concern. The aim of this multidisciplinary journal is to provide a global forum for new knowledge related to cancer survivorship. The journal publishes peer-reviewed papers relevant to improving the understanding, prevention, and management of the multiple areas related to cancer survivorship that can affect quality of care, access to care, longevity, and quality of life. It is a forum for research on humans (both laboratory and clinical), clinical studies, systematic and meta-analytic literature reviews, policy studies, and in rare situations case studies as long as they provide a new observation that should be followed up on to improve outcomes related to cancer survivors. Published articles represent a broad range of fields including oncology, primary care, physical medicine and rehabilitation, many other medical and nursing specialties, nursing, health services research, physical and occupational therapy, public health, behavioral medicine, psychology, social work, evidence-based policy, health economics, biobehavioral mechanisms, and qualitative analyses. The journal focuses exclusively on adult cancer survivors, young adult cancer survivors, and childhood cancer survivors who are young adults. Submissions must target those diagnosed with and treated for cancer.