The interaction between the nervous system and the stomatognathic system: from development to diseases.

IF 10.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

International Journal of Oral Science Pub Date : 2023-08-15 DOI:10.1038/s41368-023-00241-4

Yuzhu Wu, Yanhua Lan, Jiajie Mao, Jiahui Shen, Ting Kang, Zhijian Xie

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引用次数: 1

Abstract

The crosstalk between the nerve and stomatognathic systems plays a more important role in organismal health than previously appreciated with the presence of emerging concept of the "brain-oral axis". A deeper understanding of the intricate interaction between the nervous system and the stomatognathic system is warranted, considering their significant developmental homology and anatomical proximity, and the more complex innervation of the jawbone compared to other skeletons. In this review, we provide an in-depth look at studies concerning neurodevelopment, craniofacial development, and congenital anomalies that occur when the two systems develop abnormally. It summarizes the cross-regulation between nerves and jawbones and the effects of various states of the jawbone on intrabony nerve distribution. Diseases closely related to both the nervous system and the stomatognathic system are divided into craniofacial diseases caused by neurological illnesses, and neurological diseases caused by an aberrant stomatognathic system. The two-way relationships between common diseases, such as periodontitis and neurodegenerative disorders, and depression and oral diseases were also discussed. This review provides valuable insights into novel strategies for neuro-skeletal tissue engineering and early prevention and treatment of orofacial and neurological diseases.

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神经系统与口颌系统的相互作用:从发育到疾病。

随着“脑-口轴”概念的出现，神经和口颌系统之间的相互作用在机体健康中发挥着比以前认识到的更重要的作用。考虑到神经系统和口颌系统在发育上的同源性和解剖学上的接近性，以及颌骨与其他骨骼相比更复杂的神经支配，有必要对神经系统和口颌系统之间复杂的相互作用有更深入的了解。在这篇综述中，我们提供了一个深入的研究关于神经发育，颅面发育和先天性异常发生时，这两个系统发育异常。综述了神经与颌骨的交叉调节以及颌骨的不同状态对骨内神经分布的影响。与神经系统和口颌系统密切相关的疾病分为由神经系统疾病引起的颅面疾病和由异常的口颌系统引起的神经系统疾病。讨论了牙周炎、神经退行性疾病等常见病与抑郁症、口腔疾病之间的双向关系。这一综述为神经骨骼组织工程的新策略以及早期预防和治疗口面部和神经系统疾病提供了有价值的见解。

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来源期刊

International Journal of Oral Science DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

31.80

自引率

1.30%

发文量

审稿时长

>12 weeks

期刊介绍： The International Journal of Oral Science covers various aspects of oral science and interdisciplinary fields, encompassing basic, applied, and clinical research. Topics include, but are not limited to: Oral microbiology Oral and maxillofacial oncology Cariology Oral inflammation and infection Dental stem cells and regenerative medicine Craniofacial surgery Dental material Oral biomechanics Oral, dental, and maxillofacial genetic and developmental diseases Craniofacial bone research Craniofacial-related biomaterials Temporomandibular joint disorder and osteoarthritis The journal publishes peer-reviewed Articles presenting new research results and Review Articles offering concise summaries of specific areas in oral science.