Structural impairment in superficial and deep white matter in schizophrenia.

IF 3.8 4区 医学 Q1 Medicine
Sung Woo Joo, Young Tak Jo, Soojin Ahn, Young Jae Choi, Woohyeok Choi, Sang Kyoung Kim, Soohyun Joe, Jungsun Lee
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引用次数: 0

Abstract

Objective: Although disconnectivity among brain regions has been one of the main hypotheses for schizophrenia, the superficial white matter (SWM) has received less attention in schizophrenia research than the deep white matter (DWM) owing to the challenge of consistent reconstruction across subjects.

Methods: We obtained the diffusion magnetic resonance imaging (dMRI) data of 223 healthy controls and 143 patients with schizophrenia. After harmonising the raw dMRIs from three different studies, we performed whole-brain two-tensor tractography and fibre clustering on the tractography data. We compared the fractional anisotropy (FA) of white matter tracts between healthy controls and patients with schizophrenia. Spearman's rho was adopted for the associations with clinical symptoms measured by the Positive and Negative Syndrome Scale (PANSS). The Bonferroni correction was used to adjust multiple testing.

Results: Among the 33 DWM and 8 SWM tracts, patients with schizophrenia had a lower FA in 14 DWM and 4 SWM tracts than healthy controls, with small effect sizes. In the patient group, the FA deviations of the corticospinal and superficial-occipital tracts were negatively correlated with the PANSS negative score; however, this correlation was not evident after adjusting for multiple testing.

Conclusion: We observed the structural impairments of both the DWM and SWM tracts in patients with schizophrenia. The SWM could be a potential target of interest in future research on neural biomarkers for schizophrenia.

精神分裂症患者浅层和深层白质结构损伤。
目的:虽然脑区域之间的不连接一直是精神分裂症的主要假设之一,但由于跨受试者一致性重建的挑战,在精神分裂症研究中,浅表白质(SWM)受到的关注比深层白质(DWM)少。方法:获取223名健康对照和143名精神分裂症患者的弥散磁共振成像(dMRI)资料。在对来自三个不同研究的原始dmri进行协调后,我们对神经束造影数据进行了全脑双张量神经束造影和纤维聚类。我们比较了健康对照者和精神分裂症患者白质束的分数各向异性(FA)。阳性和阴性症状量表(PANSS)与临床症状的相关性采用Spearman's rho。采用Bonferroni校正对多重检验进行校正。结果:在33个DWM束和8个SWM束中,精神分裂症患者在14个DWM束和4个SWM束中的FA低于健康对照组,但效应量较小。患者组皮质脊髓束和枕浅束FA偏差与PANSS负评分呈负相关;然而,在调整多重检验后,这种相关性并不明显。结论:我们在精神分裂症患者中观察到DWM束和SWM束的结构损伤。SWM可能是未来精神分裂症神经生物标志物研究的潜在目标。
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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica 医学-精神病学
CiteScore
8.50
自引率
5.30%
发文量
30
审稿时长
6-12 weeks
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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