Prenatal exposure to fluoxetine modulates emotionality and aversive memory in male and female rat offspring.

IF 1.6 4区心理学 Q3 BEHAVIORAL SCIENCES

Behavioural Pharmacology Pub Date : 2022-12-01 DOI:10.1097/FBP.0000000000000705

Sarah Sophia G Linhares, Ywlliane da Silva R Meurer, Antônio Carlos Queiroz de Aquino, Diego de Aquino Câmara, Luiz Eduardo M Brandão, Felipe Porto Fiuza, Ramón Hypolito Lima, Rovena Clara J G Engelberth, Jeferson Souza Cavalcante

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引用次数: 2

Abstract

During pregnancy, women are prone to depression, for which selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, are usually the first-line treatment. However, fluoxetine can cross the placental barrier and affect fetuses, causing changes in serotonin levels early in life. Long-term effects in the brain circuits that control cognitive and emotional behavior are related to early fluoxetine exposure during development. In this study, we aimed to investigate whether fluoxetine exposure (10 mg/kg/day) from the 13th gestational day (GD13) to GD21 may lead to behavioral emotional-cognitive changes in male and female rat offspring approximately 90 days postnatally (~PN90). We have analyzed the performance of individuals in the open field and in the plus-maze discriminative avoidance task, which assesses anxiety and learning/memory processing behaviors. We have found that prenatal (GD13-GD21) exposure to fluoxetine strengthened aversive memory and induced higher anxiety levels in males, and quick extinction of aversive memory in females. Taken together, these results suggest that early exposure to fluoxetine impairs the basal state of anxiety and the cognitive functions of rats during adulthood, which may be in a sex-specific manner because males appear more susceptible than females.

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产前暴露于氟西汀可调节雄性和雌性大鼠后代的情绪和厌恶记忆。

在怀孕期间，女性容易患抑郁症，选择性血清素再摄取抑制剂(SSRIs)，如氟西汀，通常是一线治疗方法。然而，氟西汀可以穿过胎盘屏障，影响胎儿，导致生命早期血清素水平的变化。控制认知和情绪行为的大脑回路的长期影响与发育过程中早期接触氟西汀有关。在这项研究中，我们旨在研究氟西汀暴露(10 mg/kg/天)从妊娠第13天(GD13)到GD21是否会导致雄性和雌性大鼠后代在出生后约90天(~PN90)的行为情绪认知变化。我们分析了个体在开放领域和加迷宫区分回避任务中的表现，这两个任务评估了个体的焦虑和学习/记忆加工行为。我们发现，产前暴露于氟西汀(GD13-GD21)会增强男性的厌恶记忆，并导致更高的焦虑水平，而女性的厌恶记忆会迅速消失。综上所述，这些结果表明，早期接触氟西汀会损害成年期大鼠的基本焦虑状态和认知功能，这可能以性别特异性的方式存在，因为雄性比雌性更容易受到影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioural Pharmacology 医学-行为科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.