Renal adverse drug reactions.

IF 4.5 3区医学 Q2 IMMUNOLOGY

Current Opinion in HIV and AIDS Pub Date : 2021-11-01 DOI:10.1097/COH.0000000000000703

Christine Hughes

{"title":"Renal adverse drug reactions.","authors":"Christine Hughes","doi":"10.1097/COH.0000000000000703","DOIUrl":null,"url":null,"abstract":"Purpose of review: Chronic kidney disease (CKD) is common in people living with HIV (PLWH) and is related to a multitude of factors. The aim of this review is to provide an overview of the most recent evidence of renal adverse effects of antiretroviral drugs, predictors of CKD risk and areas for future research.Recent findings: Advancing age, cardiometabolic risk factors and adverse effects of antiretroviral drugs contribute to the higher prevalence of CKD in PLWH. Genetic factors and baseline clinical CKD risk are strongly correlated to risk of incident CKD, although it is unclear to what extent gene polymorphisms explain renal adverse effects related to tenofovir disoproxil fumarate (TDF). Switching from TDF to tenofovir alafenamide (TAF) in people with baseline renal dysfunction improves renal parameters; however, the long-term safety and benefit of TAF in individuals at low risk of CKD is an area of ongoing research.Summary: Several factors contribute to estimated glomerular function decline and CKD in PLWH. Clinical risk scores for CKD may be useful to inform selection of ART in an ageing population. In people with baseline renal dysfunction, potentially nephrotoxic antiretroviral drugs should be avoided.","PeriodicalId":10949,"journal":{"name":"Current Opinion in HIV and AIDS","volume":"16 6","pages":"303-308"},"PeriodicalIF":4.5000,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in HIV and AIDS","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/COH.0000000000000703","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 2

Abstract

Purpose of review: Chronic kidney disease (CKD) is common in people living with HIV (PLWH) and is related to a multitude of factors. The aim of this review is to provide an overview of the most recent evidence of renal adverse effects of antiretroviral drugs, predictors of CKD risk and areas for future research.

Recent findings: Advancing age, cardiometabolic risk factors and adverse effects of antiretroviral drugs contribute to the higher prevalence of CKD in PLWH. Genetic factors and baseline clinical CKD risk are strongly correlated to risk of incident CKD, although it is unclear to what extent gene polymorphisms explain renal adverse effects related to tenofovir disoproxil fumarate (TDF). Switching from TDF to tenofovir alafenamide (TAF) in people with baseline renal dysfunction improves renal parameters; however, the long-term safety and benefit of TAF in individuals at low risk of CKD is an area of ongoing research.

Summary: Several factors contribute to estimated glomerular function decline and CKD in PLWH. Clinical risk scores for CKD may be useful to inform selection of ART in an ageing population. In people with baseline renal dysfunction, potentially nephrotoxic antiretroviral drugs should be avoided.

查看原文本刊更多论文

肾脏药物不良反应。

综述目的:慢性肾脏疾病(CKD)在HIV感染者(PLWH)中很常见，与多种因素有关。本综述的目的是概述抗逆转录病毒药物对肾脏不良反应的最新证据，CKD风险的预测因素和未来研究的领域。最近发现:年龄增长、心脏代谢危险因素和抗逆转录病毒药物的不良反应是PLWH患者CKD患病率较高的原因。遗传因素和基线临床CKD风险与发生CKD的风险密切相关，尽管基因多态性在多大程度上解释与富马酸替诺福韦二氧吡酯(TDF)相关的肾脏不良反应尚不清楚。基线肾功能不全患者从TDF切换到替诺福韦阿拉芬胺(TAF)可改善肾脏参数;然而，TAF在低CKD风险个体中的长期安全性和益处是一个正在进行的研究领域。总结:PLWH患者肾小球功能下降和CKD的影响因素有几个。CKD的临床风险评分可能有助于老年人群ART的选择。在基线肾功能不全的人群中，应避免使用具有潜在肾毒性的抗逆转录病毒药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Opinion in HIV and AIDS IMMUNOLOGY-INFECTIOUS DISEASES

CiteScore

7.40

自引率

7.30%

发文量

115

审稿时长

6-12 weeks

期刊介绍： Published bimonthly and offering a unique and wide ranging perspective on the key developments in the field, each issue of Current Opinion in HIV and AIDS features hand-picked review articles from our team of expert editors. With six disciplines published across the year – including HIV and ageing, a HIV vaccine, and epidemiology – every issue also contains annotated reference detailing the merits of the most important papers.