Ferroptosis in cancer immunity and immunotherapy: Multifaceted interplay and clinical implications

IF 9.3 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine & Growth Factor Reviews Pub Date : 2024-02-01 DOI:10.1016/j.cytogfr.2023.08.004

Xiaoqian Zhai , Yiyun Lin , Lingling Zhu , Yuqing Wang , Jiabi Zhang , Jiewei Liu , Lu Li , Xiaojie Lu

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引用次数: 0

Abstract

Ferroptosis is a type of cell death characterized by iron-dependent phospholipid peroxidation and reactive oxygen species overproduction. Ferroptosis induces immunogenic cell death and elicits anti-tumor immune responses, playing an important role in cancer immunotherapy. Ferroptosis suppression in cancer cells impairs its immunotherapeutic efficacy. To overcome this issue, ferroptosis inducers (FINs) have been combined with other cancer therapies to create an anti-tumor immune microenvironment. However, the ferroptosis-based crosstalk between immune and tumor cells is complex because oxidative products released by ferroptotic tumor cells impair the functions of anti-tumor immune cells, resulting in immunotherapeutic resistance. In the present article, we have reviewed ferroptosis in tumor and immune cells and summarized the crosstalk between ferroptotic tumor cells and the immune microenvironment. Based on the existing literature, we have further discussed future perspectives on opportunities for combining ferroptosis-targeted therapies with cancer immunotherapies.

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癌症免疫和免疫疗法中的铁蛋白沉积：多方面的相互作用和临床意义

铁变态反应是一种细胞死亡，其特点是铁依赖性磷脂过氧化和活性氧过量产生。铁氧化诱导免疫原性细胞死亡，引起抗肿瘤免疫反应，在癌症免疫疗法中发挥着重要作用。抑制癌细胞中的铁突变会损害其免疫治疗效果。为了克服这一问题，人们将铁突变诱导剂（FINs）与其他癌症疗法相结合，以创造抗肿瘤免疫微环境。然而，免疫细胞和肿瘤细胞之间基于铁变态反应的串扰是复杂的，因为铁变态反应肿瘤细胞释放的氧化产物会损害抗肿瘤免疫细胞的功能，从而导致免疫治疗抵抗。本文综述了肿瘤和免疫细胞中的铁凋亡，并总结了铁凋亡肿瘤细胞与免疫微环境之间的相互影响。在现有文献的基础上，我们进一步探讨了未来将铁突变靶向疗法与癌症免疫疗法相结合的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine & Growth Factor Reviews 生物-生化与分子生物学

CiteScore

21.10

自引率

1.50%

发文量

审稿时长

22 days

期刊介绍： Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.