Neurobiological correlates of resilience during childhood and adolescence – A systematic review

IF 13.7 1区心理学 Q1 PSYCHOLOGY, CLINICAL

Clinical Psychology Review Pub Date : 2023-09-09 DOI:10.1016/j.cpr.2023.102333

Lu Zhang , Divyangana Rakesh , Vanessa Cropley , Sarah Whittle

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Abstract

Research examining the neurobiological mechanisms of resilience has grown rapidly over the past decade. However, there is vast heterogeneity in research study design, methods, and in how resilience is operationalized, making it difficult to gauge what we currently know about resilience biomarkers. This preregistered systematic review aimed to review and synthesize the extant literature to identify neurobiological correlates of resilience to adversity during childhood and adolescence. Literature searches on MEDLINE and PsycINFO yielded 3834 studies and a total of 49 studies were included in the final review. Findings were synthesized based on how resilience was conceptualized (e.g., absence of psychopathology, trait resilience), and where relevant, the type of outcome examined (e.g., internalizing symptoms, post-traumatic stress disorder). Our synthesis showed that findings were generally mixed. Nevertheless, some consistent findings suggest that resilience neural mechanisms may involve prefrontal and subcortical regions structure/activity, as well as connectivity between these regions. Given substantial heterogeneity in the definition and operationalization of resilience, more methodological consistency across studies is required for advancing knowledge in this field.

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儿童和青少年时期恢复力的神经生物学相关性——一项系统综述。

在过去的十年里，研究恢复力的神经生物学机制的研究迅速发展。然而，研究设计、方法以及恢复力的运作方式存在巨大的异质性，这使得我们很难衡量我们目前对恢复力生物标志物的了解。这篇预先注册的系统综述旨在回顾和综合现有文献，以确定儿童和青少年时期逆境恢复力的神经生物学相关性。MEDLINE和PsycINFO上的文献检索产生了3834项研究，共有49项研究被纳入最终综述。研究结果是根据韧性的概念化方式（例如，缺乏精神病理学、特质韧性）以及相关的检查结果类型（例如，内化症状、创伤后应激障碍）进行综合的。我们的综合研究表明，研究结果总体上喜忧参半。然而，一些一致的发现表明，恢复力神经机制可能涉及前额叶和皮层下区域的结构/活动，以及这些区域之间的连接。鉴于复原力的定义和操作存在很大的异质性，需要在研究中保持更大的方法一致性，以推进该领域的知识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Psychology Review PSYCHOLOGY, CLINICAL-

CiteScore

23.10

自引率

1.60%

发文量

期刊介绍： Clinical Psychology Review serves as a platform for substantial reviews addressing pertinent topics in clinical psychology. Encompassing a spectrum of issues, from psychopathology to behavior therapy, cognition to cognitive therapies, behavioral medicine to community mental health, assessment, and child development, the journal seeks cutting-edge papers that significantly contribute to advancing the science and/or practice of clinical psychology. While maintaining a primary focus on topics directly related to clinical psychology, the journal occasionally features reviews on psychophysiology, learning therapy, experimental psychopathology, and social psychology, provided they demonstrate a clear connection to research or practice in clinical psychology. Integrative literature reviews and summaries of innovative ongoing clinical research programs find a place within its pages. However, reports on individual research studies and theoretical treatises or clinical guides lacking an empirical base are deemed inappropriate for publication.