The use of angiotensin receptor blockers in dementia prevention.

Q3 Medicine

Dementia e Neuropsychologia Pub Date : 2023-01-01 DOI:10.1590/1980-5764-DN-2023-3006

Jordana de Araujo Müller, Laura Jacques Giacobe, Vanise Grassi, André Luiz Rodrigues Palmeira

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引用次数: 0

Abstract

Alzheimer's disease (AD) and dementia are preventable and highly prevalent diseases, as is systemic arterial hypertension. Thus, it is speculated that angiotensin receptor blockers (ARBs) may be neuroprotective against AD.

Objective: The aim of this study was to evaluate if the use of ARBs confers a neuroprotective effect on AD, through a systematic review.

Methods: Studies published on Embase, LILACS, SciELO, and PubMed were evaluated. The selection of the studies included those that evaluated the use of antihypertensive drugs in individuals with a previous diagnosis of mild cognitive impairment. The data were extracted with the Cochrane Effective Practice and Organization of Care (EPOC) form. The risk of bias was evaluated by the EPOC "Risk of bias tool."

Results: A total of 12 articles were identified, and 3 articles were selected. Two of them analyzed the use of ARB/ACEI versus other antihypertensives and the development of dementia.

Conclusion: There is a tendency for ARBs to be superior to other antihypertensives in preventing dementia.

Abstract Image

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血管紧张素受体阻滞剂在痴呆预防中的应用。

阿尔茨海默病(AD)和痴呆症是可以预防和高度流行的疾病，系统性动脉高血压也是如此。因此，推测血管紧张素受体阻滞剂(ARBs)可能对AD具有神经保护作用。目的:本研究的目的是通过系统评价arb是否对AD具有神经保护作用。方法:对发表在Embase、LILACS、SciELO和PubMed上的研究进行评价。研究的选择包括那些评估抗高血压药物在先前诊断为轻度认知障碍的个体中的使用。数据采用Cochrane有效实践与护理组织(EPOC)表格提取。偏倚风险采用EPOC“偏倚风险工具”进行评估。结果:共识别出12篇文章，筛选出3篇。其中两项研究分析了ARB/ACEI与其他抗高血压药物的使用和痴呆的发展。结论:ARBs在预防痴呆方面有优于其他抗高血压药物的趋势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dementia e Neuropsychologia Medicine-Geriatrics and Gerontology

CiteScore

2.20

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： Dementia top Neuropsychologia the official scientific journal of the Cognitive Neurology and Ageing Department of the Brazilian Academy of Neurology and of the Brazilian Association of Geriatric Neuropsychiatry, is published by the "Associação Neurologia Cognitiva e do Comportamento", a nonprofit Brazilian association. Regularly published on March, June, September, and December since 2007.