Comprehensive Analysis to Identify LINC00511-hsa-miR-625-5p-SEMA6A Pathway Fuels Progression of Skin Cutaneous Melanoma.

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

International Journal of Genomics Pub Date : 2023-01-01 DOI:10.1155/2023/6422941

Guanghua Chen, Jia Yan, Zhou Fu

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引用次数: 0

Abstract

Objective: Skin cutaneous melanoma (SKCM) is a highly lethal malignancy that poses a significant threat to human health. Recent research has shown that competing endogenous RNA (ceRNA) regulatory networks play a critical role in the development and progression of various types of cancer, including SKCM. The objective of this study is to investigate the ceRNA regulatory network associated with the transmembrane protein semaphorin 6A (SEMA6A) and identify the underlying molecular mechanisms involved in SKCM.

Methods: Expression profiles of four RNAs, including pseudogenes, long non-coding RNAs, microRNAs, and mRNAs were obtained from The Cancer Genome Atlas database. The analysis was completed by bioinformatics methods, and the expression levels of the selected genes were verified by cell experiments.

Results: Bioinformatics analysis revealed that the LINC00511-hsa-miR-625-5p-SEMA6A ceRNA network was associated with SKCM prognosis. Furthermore, immune infiltration analysis indicated that the LINC00511-hsa-miR-625-5p-SEMA6A axis may have an impact on changes in the tumor immune microenvironment of SKCM.

Conclusion: The LINC00511-hsa-miR-625-5p-SEMA6A axis could be a promising therapeutic target and a prognostic biomarker for SKCM.

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综合分析鉴定LINC00511-hsa-miR-625-5p-SEMA6A通路促进皮肤黑色素瘤的进展

目的:皮肤黑色素瘤(SKCM)是一种严重威胁人类健康的高致死率恶性肿瘤。最近的研究表明，竞争内源性RNA (ceRNA)调控网络在包括SKCM在内的各种类型癌症的发生和进展中起着关键作用。本研究的目的是研究与跨膜蛋白信号蛋白6A (SEMA6A)相关的ceRNA调控网络，并确定参与SKCM的潜在分子机制。方法:从The Cancer Genome Atlas数据库中获取4种rna的表达谱，包括假基因、长链非编码rna、microRNAs和mrna。通过生物信息学方法完成分析，并通过细胞实验验证所选基因的表达水平。结果:生物信息学分析显示，LINC00511-hsa-miR-625-5p-SEMA6A ceRNA网络与SKCM预后相关。此外，免疫浸润分析提示LINC00511-hsa-miR-625-5p-SEMA6A轴可能影响SKCM肿瘤免疫微环境的变化。结论:LINC00511-hsa-miR-625-5p-SEMA6A轴可能是一个有希望的治疗靶点和SKCM的预后生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Genomics BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOTECHNOLOGY & APPLIED MICROBIOLOGY

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： International Journal of Genomics is a peer-reviewed, Open Access journal that publishes research articles as well as review articles in all areas of genome-scale analysis. Topics covered by the journal include, but are not limited to: bioinformatics, clinical genomics, disease genomics, epigenomics, evolutionary genomics, functional genomics, genome engineering, and synthetic genomics.