Cardiovascular disease risk in women living with HIV.

IF 4.5 3区医学 Q2 IMMUNOLOGY

Current Opinion in HIV and AIDS Pub Date : 2022-09-01 DOI:10.1097/COH.0000000000000756

Katherine Kentoffio, Tecla M Temu, Saate S Shakil, Markella V Zanni, Chris T Longenecker

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引用次数: 1

Abstract

Purpose of review: To synthesize current evidence on the impact of cardiovascular disease among women living with HIV (WLWH) with a particular focus on disease prevalence, mechanisms and prevention.

Recent findings: HIV-related cardiovascular disease risk is 1.5-fold to 2-fold higher for women than for men. Mechanisms of enhanced risk are multifactorial and include reinforcing pathways between traditional risk factors, metabolic dysregulation, early reproductive aging and chronic immune activation. These pathways influence both the presentation of overt syndromes of myocardial infarction, stroke and heart failure, as well as subclinical disease, such as microvascular dysfunction and cardiac fibrosis. Cardiovascular disease, therefore, remains a consistent threat to healthy aging among WLWH.

Summary: Although no specific prevention strategies exist, patient-centered risk mitigation approaches that are adaptable to the needs of aging individuals are essential to combat disparities in cardiovascular outcomes among WLWH. Further research into the optimal prevention approach for CVD among WLWH, particularly for women living in under-resourced health systems, is needed.

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感染艾滋病毒的妇女患心血管疾病的风险。

综述的目的:综合目前关于心血管疾病对感染艾滋病毒的妇女(WLWH)影响的证据，特别关注疾病流行、机制和预防。最近的研究发现:与艾滋病毒相关的心血管疾病风险，女性比男性高1.5至2倍。风险增加的机制是多因素的，包括传统风险因素之间的强化途径、代谢失调、早期生殖衰老和慢性免疫激活。这些途径既影响心肌梗死、中风和心力衰竭的显性综合征的表现，也影响亚临床疾病，如微血管功能障碍和心脏纤维化。因此，心血管疾病仍然是低龄妇女健康老龄化的一贯威胁。摘要:虽然没有具体的预防策略，但适应老年人需求的以患者为中心的风险缓解方法对于消除WLWH之间心血管结局的差异至关重要。需要进一步研究WLWH中预防心血管疾病的最佳方法，特别是生活在资源不足的卫生系统中的妇女。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in HIV and AIDS IMMUNOLOGY-INFECTIOUS DISEASES

CiteScore

7.40

自引率

7.30%

发文量

115

审稿时长

6-12 weeks

期刊介绍： Published bimonthly and offering a unique and wide ranging perspective on the key developments in the field, each issue of Current Opinion in HIV and AIDS features hand-picked review articles from our team of expert editors. With six disciplines published across the year – including HIV and ageing, a HIV vaccine, and epidemiology – every issue also contains annotated reference detailing the merits of the most important papers.