Lower Extremity Injury Risk Curve Development for a Human Body Model in the Underbody Blast Environment.

IF 1.7 4区 医学 Q4 BIOPHYSICS
Zachary S Hostetler, F Scott Gayzik
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Abstract

Computational human body models (HBMs) provide the ability to explore numerous candidate injury metrics ranging from local strain based criteria to global combined criteria such as the Tibia Index. Despite these efforts, there have been relatively few studies that focus on determining predicted injury risk from HBMs based on observed postmortem human subjects (PMHS) injury data. Additionally, HBMs provide an opportunity to construct risk curves using measures that are difficult or impossible to obtain experimentally. The Global Human Body Models Consortium (GHBMC) M50-O v 6.0 lower extremity was simulated in 181 different loading conditions based on previous PMHS tests in the underbody blast (UBB) environment and 43 different biomechanical metrics were output. The Brier Metric Score were used to determine the most appropriate metric for injury risk curve development. Using survival analysis, three different injury risk curves (IRC) were developed: "any injury," "calcaneus injury," and "tibia injury." For each injury risk curve, the top three metrics selected using the Brier Metric Score were tested for significant covariates including boot use and posture. The best performing metric for the "any injury," "calcaneus injury" and "tibia injury" cases were calcaneus strain, calcaneus force, and lower tibia force, respectively. For the six different injury risk curves where covariates were considered, the presence of the boot was found to be a significant covariate reducing injury risk in five out of six cases. Posture was significant for only one curve. The injury risk curves developed from this study can serve as a baseline for model injury prediction, personal protective equipment (PPE) evaluation, and can aid in larger scale testing and experimental protocols.

人体模型在车身底部爆炸环境中下肢受伤风险曲线的开发。
计算人体模型(HBM)提供了探索众多候选损伤指标的能力,从基于局部应变的标准到胫骨指数等全球综合标准。尽管做出了这些努力,但基于观察到的死后人体(PMHS)损伤数据,通过 HBM 确定预测损伤风险的研究相对较少。此外,HBM 还提供了一个机会,可以使用难以或无法通过实验获得的指标来构建风险曲线。全球人体模型联盟(GHBMC)的 M50-O v 6.0 下肢在 181 种不同的加载条件下进行了模拟,这些条件是基于以前在躯体下爆炸(UBB)环境中进行的 PMHS 测试,并输出了 43 种不同的生物力学指标。布赖尔指标评分用于确定最适合制定损伤风险曲线的指标。通过生存分析,制定了三种不同的损伤风险曲线(IRC):"任何损伤"、"小腿损伤 "和 "胫骨损伤"。对于每种受伤风险曲线,使用布赖尔指标评分法选出的前三个指标都进行了重要协变量测试,包括靴子的使用和姿势。在 "任何损伤"、"小关节损伤 "和 "胫骨损伤 "情况下,表现最好的指标分别是小关节应变、小关节力和胫骨下端力。在考虑协变量的六种不同的受伤风险曲线中,发现在六种情况中的五种情况下,靴子的存在是降低受伤风险的重要协变量。姿势只对一条曲线有显著影响。本研究得出的伤害风险曲线可作为模型伤害预测、个人防护设备(PPE)评估的基线,并有助于更大规模的测试和实验方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.40
自引率
5.90%
发文量
169
审稿时长
4-8 weeks
期刊介绍: Artificial Organs and Prostheses; Bioinstrumentation and Measurements; Bioheat Transfer; Biomaterials; Biomechanics; Bioprocess Engineering; Cellular Mechanics; Design and Control of Biological Systems; Physiological Systems.
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