Possible impact of HLA class I and class II on malignancies driven by a single germ-line BRCA1 mutation

IF 2.3 4区医学 Q3 GENETICS & HEREDITY

International Journal of Immunogenetics Pub Date : 2023-07-28 DOI:10.1111/iji.12631

Milena Ivanova, Anastasia Ormandjieva, Rumyana Dodova, Radka Kaneva, Velizar Shivarov

引用次数: 0

Abstract

This study provides the first immunogenetic preliminary evidence that specific human leucocyte antigen (HLA) class I and class II alleles and haplotypes may be relevant for BRCA1 c.5263_5264insC driven oncogenesis. Observed HLA associations might have practical implications for establishment of predictive markers for the response to immunotherapies in malignancies driven by this germ-line mutation.

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HLA I类和II类对由单一种系BRCA1突变驱动的恶性肿瘤的可能影响

该研究首次提供了免疫遗传学的初步证据，证明特异性人类白细胞抗原(HLA) I类和II类等位基因和单倍型可能与BRCA1 c.5263_5264insC驱动的肿瘤发生有关。观察到的HLA相关性可能对建立由这种种系突变驱动的恶性肿瘤免疫治疗反应的预测标记具有实际意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Immunogenetics 医学-免疫学

CiteScore

4.70

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The International Journal of Immunogenetics (formerly European Journal of Immunogenetics) publishes original contributions on the genetic control of components of the immune system and their interactions in both humans and experimental animals. The term ''genetic'' is taken in its broadest sense to include studies at the evolutionary, molecular, chromosomal functional and population levels in both health and disease. Examples are: -studies of blood groups and other surface antigens- cell interactions and immune response- receptors, antibodies, complement components and cytokines- polymorphism- evolution of the organisation, control and function of immune system components- anthropology and disease associations- the genetics of immune-related disease: allergy, autoimmunity, immunodeficiency and other immune pathologies- All papers are seen by at least two independent referees and only papers of the highest quality are accepted.