Aerobic and Resistance Training Attenuate Differently Knee Joint Damage Caused by a High-Fat-High-Sucrose Diet in a Rat Model.

IF 2.7 4区 医学 Q1 ORTHOPEDICS
CARTILAGE Pub Date : 2024-12-01 Epub Date: 2023-09-01 DOI:10.1177/19476035231193090
Nada Abughazaleh, Kevin Boldt, Jaqueline Lourdes Rios, Stela Marcia Mattiello, Kelsey H Collins, Ruth-Anne Seerattan, Walter Herzog
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Abstract

Objective: Obesity and associated low-level local systemic inflammation have been linked to an increased rate of developing knee osteoarthritis (OA). Aerobic exercise has been shown to protect the knee from obesity-induced joint damage. The aims of this study were to determine (1) if resistance training provides beneficial metabolic effects similar to those previously observed with aerobic training in rats consuming a high-fat/high-sucrose (HFS) diet and (2) if these metabolic effects mitigate knee OA in a diet-induced obesity model in rats.

Design: Twelve-week-old Sprague-Dawley rats were randomized into 4 groups: (1) a group fed an HFS diet subjected to aerobic exercise (HFS+Aer), (2) a group fed an HFS diet subjected to resistance exercise (HFS+Res), (3) a group fed an HFS diet with no exercise (HFS+Sed), and (4) a chow-fed sedentary control group (Chow+Sed). HFS+Sed animals were heavier and had greater body fat, higher levels of triglycerides and total cholesterol, and more joint damage than Chow+Sed animals.

Results: The HFS+Res group had higher body mass and body fat than Chow+Sed animals and higher OA scores than animals from the HFS+Aer group. Severe bone lesions were observed in the HFS+Sed and Chow+Sed animals at age 24 weeks, but not in the HFS+Res and HFS+Aer group animals.

Conclosion: In summary, aerobic training provided better protection against knee joint OA than resistance training in this rat model of HFS-diet-induced obesity. Exposing rats to exercise, either aerobic or resistance training, had a protective effect against the severe bone lesions observed in the nonexercised rats.

在大鼠模型中,有氧训练和阻力训练可不同程度地减轻高脂高蔗糖饮食对膝关节造成的损伤。
目的:肥胖和相关的低水平局部系统炎症与膝关节骨性关节炎(OA)发病率增加有关。有氧运动可保护膝关节免受肥胖引起的关节损伤。本研究的目的是确定:(1)阻力训练是否能提供有益的新陈代谢效应,类似于之前在摄入高脂肪/高蔗糖(HFS)饮食的大鼠身上观察到的有氧训练效应;(2)这些新陈代谢效应是否能减轻饮食诱导肥胖模型大鼠的膝关节OA:设计:将12周大的Sprague-Dawley大鼠随机分为4组:(1) 以HFS饮食喂养并进行有氧运动的一组(HFS+Aer),(2) 以HFS饮食喂养并进行阻力运动的一组(HFS+Res),(3) 以HFS饮食喂养但不进行任何运动的一组(HFS+Sed),(4) 以饲料喂养但久坐不动的对照组(Chow+Sed)。与 Chow+Sed 动物相比,HFS+Sed 动物体重更重,体脂更高,甘油三酯和总胆固醇水平更高,关节损伤更严重:HFS+Res组动物的体重和体脂高于Chow+Sed组动物,OA评分高于HFS+Aer组动物。HFS+Sed组和Chow+Sed组动物在24周龄时出现了严重的骨损伤,而HFS+Res组和HFS+Aer组动物则没有:总之,在这种 HFS 饮食诱发肥胖的大鼠模型中,有氧训练比阻力训练能更好地保护膝关节免受 OA 侵袭。让大鼠参加有氧运动或阻力训练,对未参加运动的大鼠观察到的严重骨损伤具有保护作用。
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来源期刊
CARTILAGE
CARTILAGE ORTHOPEDICS-
CiteScore
6.90
自引率
7.10%
发文量
80
期刊介绍: CARTILAGE publishes articles related to the musculoskeletal system with particular attention to cartilage repair, development, function, degeneration, transplantation, and rehabilitation. The journal is a forum for the exchange of ideas for the many types of researchers and clinicians involved in cartilage biology and repair. A primary objective of CARTILAGE is to foster the cross-fertilization of the findings between clinical and basic sciences throughout the various disciplines involved in cartilage repair. The journal publishes full length original manuscripts on all types of cartilage including articular, nasal, auricular, tracheal/bronchial, and intervertebral disc fibrocartilage. Manuscripts on clinical and laboratory research are welcome. Review articles, editorials, and letters are also encouraged. The ICRS envisages CARTILAGE as a forum for the exchange of knowledge among clinicians, scientists, patients, and researchers. The International Cartilage Repair Society (ICRS) is dedicated to promotion, encouragement, and distribution of fundamental and applied research of cartilage in order to permit a better knowledge of function and dysfunction of articular cartilage and its repair.
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