Co-administration of bromocriptine and corticosterone produces short- and long-lasting reduction in intake of high-fat food in male rats.

IF 1.6 4区 心理学 Q3 BEHAVIORAL SCIENCES
Víctor H Castillo-Campohermoso, Luz M Molina-Martínez, Eliana Barrios de Tomasi, Jorge Juárez
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引用次数: 0

Abstract

Dopaminergic and glucocorticoid activity has been associated with reduced food consumption; however, their possible synergic action has not yet been studied. With the aim of examining the effect of the co-administration of the dopamine receptor D2 agonist bromocriptine and corticosterone on palatable food intake, male Wistar rats were administered either bromocriptine (1 mg/kg), corticosterone (2 mg/kg), bromocriptine + corticosterone (1 mg + 2 mg/kg) or a vehicle, with a fifth group used as a control. In all cases, substances were administered 30 min before exposure to standard food or palatable food, the latter high in carbohydrates [high carbohydrate food (HCF), 75%] or high-fat food (HFF, 67%). Food consumption and body weight were recorded daily. Results showed higher consumption of standard food but lower consumption of HCF and HFF in the groups that received bromocriptine, alone or in combination. In general, lower total kcal intake was observed in the bromocriptine and bromocriptine + corticosterone groups during the period of pharmacological treatment and following re-exposure to palatable food. The low HFF intake in the bromocriptine + corticosterone group persisted 10 days after the pharmacological treatment was interrupted. This effect suggests plastic changes in either the mechanisms involved in the incentive value of palatable food - particularly foods with high-fat content - or those that regulate lipid metabolism. Our findings suggest that homeostatic and reward mechanisms could be influenced by the co-participation of the dopaminergic and hypothalamic-pituitary-adrenal systems, and the macronutrient content of food.

溴隐亭和皮质酮的共同管理产生短期和长期减少雄性大鼠的高脂肪食物的摄入。
多巴胺能和糖皮质激素活性与食物消耗减少有关;然而,它们可能的协同作用尚未被研究。为了研究多巴胺受体D2激动剂溴隐亭和皮质酮共同给药对美味食物摄入的影响,雄性Wistar大鼠分别给药溴隐亭(1mg /kg)、皮质酮(2mg /kg)、溴隐亭+皮质酮(1mg + 2mg /kg)或载药,第五组作为对照。在所有情况下,在暴露于标准食物或美味食物前30分钟给药,后者是高碳水化合物[高碳水化合物食物(HCF), 75%]或高脂肪食物(HFF, 67%)。每天记录食物消耗量和体重。结果显示,单独或联合使用溴隐亭组的标准食品消耗量较高,但HCF和HFF消耗量较低。总的来说,在药物治疗期间和再次暴露于美味食物后,溴隐亭组和溴隐亭+皮质酮组的总卡路里摄入量较低。溴隐亭+皮质酮组HFF低摄入量在药物治疗中断后持续10天。这种效应表明,美味食物(尤其是高脂肪食物)的刺激价值机制或调节脂质代谢的机制发生了可塑性变化。我们的研究结果表明,稳态和奖励机制可能受到多巴胺能和下丘脑-垂体-肾上腺系统以及食物中大量营养素含量的共同参与的影响。
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来源期刊
Behavioural Pharmacology
Behavioural Pharmacology 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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