Interoceptive regulation of skeletal tissue homeostasis and repair.

IF 14.3 1区 医学 Q1 CELL & TISSUE ENGINEERING
Yao Xiao, Changhao Han, Yunhao Wang, Xinshu Zhang, Rong Bao, Yuange Li, Huajiang Chen, Bo Hu, Shen Liu
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引用次数: 0

Abstract

Recent studies have determined that the nervous system can sense and respond to signals from skeletal tissue, a process known as skeletal interoception, which is crucial for maintaining bone homeostasis. The hypothalamus, located in the central nervous system (CNS), plays a key role in processing interoceptive signals and regulating bone homeostasis through the autonomic nervous system, neuropeptide release, and neuroendocrine mechanisms. These mechanisms control the differentiation of mesenchymal stem cells into osteoblasts (OBs), the activation of osteoclasts (OCs), and the functional activities of bone cells. Sensory nerves extensively innervate skeletal tissues, facilitating the transmission of interoceptive signals to the CNS. This review provides a comprehensive overview of current research on the generation and coordination of skeletal interoceptive signals by the CNS to maintain bone homeostasis and their potential role in pathological conditions. The findings expand our understanding of intersystem communication in bone biology and may have implications for developing novel therapeutic strategies for bone diseases.

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骨骼组织稳态和修复的感受性调节。
最近的研究已经确定,神经系统可以感知和响应来自骨骼组织的信号,这一过程被称为骨骼内感受,对维持骨骼稳态至关重要。下丘脑位于中枢神经系统(CNS),通过自主神经系统、神经肽释放和神经内分泌机制在处理内感受信号和调节骨稳态方面发挥着关键作用。这些机制控制间充质干细胞向成骨细胞(OBs)的分化、破骨细胞(OCs)的激活以及骨细胞的功能活性。感觉神经广泛支配骨骼组织,促进内感受信号向中枢神经系统的传递。这篇综述对中枢神经系统产生和协调骨骼内感受信号以维持骨骼稳态及其在病理条件下的潜在作用的研究现状进行了全面综述。这些发现扩展了我们对骨生物学中系统间通讯的理解,并可能对开发新的骨疾病治疗策略具有启示意义。
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来源期刊
Bone Research
Bone Research CELL & TISSUE ENGINEERING-
CiteScore
20.00
自引率
4.70%
发文量
289
审稿时长
20 weeks
期刊介绍: Established in 2013, Bone Research is a newly-founded English-language periodical that centers on the basic and clinical facets of bone biology, pathophysiology, and regeneration. It is dedicated to championing key findings emerging from both basic investigations and clinical research concerning bone-related topics. The journal's objective is to globally disseminate research in bone-related physiology, pathology, diseases, and treatment, contributing to the advancement of knowledge in this field.
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