Preoperative pregabalin prevents succinylcholine-induced fasciculation and myalgia: A meta-analysis of randomized trials

Revista espanola de anestesiologia y reanimacion Pub Date : 2024-04-01 DOI:10.1016/j.redare.2022.12.002

P.A. Vélez , V. Lara-Erazo , A.F. Caballero-Lozada , A. Botero , G. Lozada , A.F. Velásquez , L.M. Villegas , A. Zorrilla-Vaca

{"title":"Preoperative pregabalin prevents succinylcholine-induced fasciculation and myalgia: A meta-analysis of randomized trials","authors":"P.A. Vélez , V. Lara-Erazo , A.F. Caballero-Lozada , A. Botero , G. Lozada , A.F. Velásquez , L.M. Villegas , A. Zorrilla-Vaca","doi":"10.1016/j.redare.2022.12.002","DOIUrl":null,"url":null,"abstract":"<div>Succinylcholine is the gold standard neuromuscular blocker for rapid sequence induction; however, its use is associated with fasciculation and myalgia. We performed a systematic review and meta-analysis of randomized controlled clinical trials comparing gabapentinoids versus placebo for the prevention of fasciculations and succinylcholine-induced myalgias. Six randomized clinical studies were included with a total of 481 patients - 241 in the intervention group and 240 in the placebo group. Gabapentinoids reduced the incidence of succinylcholine-induced myalgia (RR  <=0.71, 95% CI 0.54−0.93, P  .013) and gabapentin (RR  =.001) separately. There was no difference in fasciculations between the groups (RR=0.92, 95% CI 0.82–1.03, P   <!-->h of surgery.</div>","PeriodicalId":94196,"journal":{"name":"Revista espanola de anestesiologia y reanimacion","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista espanola de anestesiologia y reanimacion","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2341192923001348","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Succinylcholine is the gold standard neuromuscular blocker for rapid sequence induction; however, its use is associated with fasciculation and myalgia. We performed a systematic review and meta-analysis of randomized controlled clinical trials comparing gabapentinoids versus placebo for the prevention of fasciculations and succinylcholine-induced myalgias. Six randomized clinical studies were included with a total of 481 patients - 241 in the intervention group and 240 in the placebo group. Gabapentinoids reduced the incidence of succinylcholine-induced myalgia (RR = 0.69, 95% CI 0.56−0.84, P < .001), which remained statistically significant for pregabalin (RR = 0.71, 95% CI 0.54−0.93, P = .013) and gabapentin (RR = 0.61, 95% CI 0.45−0.82, P = .001) separately. There was no difference in fasciculations between the groups (RR = 0.92, 95% CI 0.82–1.03, P = .148). Preoperative use of gabapentinoids is associated with lower incidence of succinylcholine-induced myalgias within the first 24 h of surgery.

查看原文本刊更多论文

术前服用普瑞巴林可预防琥珀胆碱诱发的筋膜痉挛和肌痛：随机试验荟萃分析

琥珀胆碱是用于快速序列诱导的金标准神经肌肉阻滞剂，但其使用与筋膜炎和肌痛有关。我们对随机对照临床试验进行了系统回顾和荟萃分析，比较了加巴喷丁类药物和安慰剂在预防筋束收缩和琥珀胆碱诱发肌痛方面的效果。六项随机临床研究共纳入了 481 名患者，其中干预组 241 人，安慰剂组 240 人。加巴喷丁类药物降低了琥珀酰胆碱引起的肌痛的发生率（RR = 0.69，95% CI 0.56-0.84，P = 0.001），普瑞巴林（RR = 0.71，95% CI 0.54-0.93，P = 0.013）和加巴喷丁（RR = 0.61，95% CI 0.45-0.82，P = 0.001）分别降低了肌痛的发生率。两组间的筋膜炎没有差异（RR = 0.92，95% CI 0.82-1.03，P = .148）。术前使用加巴喷丁类药物可降低术后 24 小时内琥珀胆碱诱发肌痛的发生率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Revista espanola de anestesiologia y reanimacion

自引率

0.00%

发文量