HPV16 status might correlate to increasing tumor-infiltrating lymphocytes in hypopharyngeal cancer.

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

Acta Oto-Laryngologica Pub Date : 2023-05-01 DOI:10.1080/00016489.2023.2221288

Mengyou Ji, Lan Lin, Qiang Huang, Chunyan Hu, Ming Zhang

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引用次数: 2

Abstract

Background: Human papillomavirus (HPV) plays a major etiological role in the increasing number of patients with head and neck squamous cell carcinoma (HNSCC).

Objectives: This study aimed at exploring the relationship between HPV infection and prognosis in patients with hypopharyngeal carcinoma (HPSCC).

Methods: We retrospectively analyzed 108 consecutive patients diagnosed with HPSCC from 2015 to 2018. Real-time fluorescent quantitative PCR and P16 immunohistochemistry were used to detect HPV infection in tissues of patients with hypopharyngeal carcinoma. The numbers of CD8, CD4 and Foxp3 cells in tumor parenchyma were obtained by immunohistochemical counting. Finally, the analysis was performed according to the clinicopathological variables and prognosis of the patients.

Results: Among 108 patients with HPSCC, 18 cases were detected by qPCR, and 16 subtypes accounted for the majority (77.8%). Kaplan-Meier analysis showed that HPV16+, higher CD8+, higher CD4+ and higher FoxP3+ TIL infiltration was strongly associated with superior three-year disease-free survival (DFS), cancer-specific survival (CSS) and overall survival (OS). Univariate analysis showed that HPV and CD4+ TIL had higher predictive value for prognosis.

Conclusions: HPV16 infection is significantly related to tumor immune infiltrating cells (TILs).

查看原文本刊更多论文

HPV16状态可能与下咽癌中肿瘤浸润淋巴细胞的增加有关。

背景:人乳头瘤病毒(HPV)在头颈部鳞状细胞癌(HNSCC)患者数量增加中起着主要的病因学作用。目的:探讨下咽癌(HPSCC)患者HPV感染与预后的关系。方法:回顾性分析2015年至2018年连续诊断为HPSCC的108例患者。采用实时荧光定量PCR和P16免疫组化检测下咽癌患者组织中HPV感染情况。免疫组化计数肿瘤组织中CD8、CD4和Foxp3细胞的数量。最后根据患者的临床病理指标及预后进行分析。结果:108例HPSCC患者中，qPCR检出18例，16个亚型占多数(77.8%)。Kaplan-Meier分析显示，HPV16+、较高的CD8+、较高的CD4+和较高的FoxP3+ TIL浸润与较好的三年无病生存期(DFS)、癌症特异性生存期(CSS)和总生存期(OS)密切相关。单因素分析显示，HPV和CD4+ TIL对预后有较高的预测价值。结论:HPV16感染与肿瘤免疫浸润细胞(TILs)有显著相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Oto-Laryngologica 医学-耳鼻喉科学

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

3-6 weeks

期刊介绍： Acta Oto-Laryngologica is a truly international journal for translational otolaryngology and head- and neck surgery. The journal presents cutting-edge papers on clinical practice, clinical research and basic sciences. Acta also bridges the gap between clinical and basic research.