Frailty phenotype is associated with antiretroviral exposure among older persons living with HIV.

IF 4.5 3区医学 Q2 IMMUNOLOGY

Current Opinion in HIV and AIDS Pub Date : 2021-09-01 DOI:10.1097/COH.0000000000000695

Gwendoline Felker, Patricia Enel, Nathalie Petit, Frederique Retornaz, Albert Darque, Isabelle Ravaux

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引用次数: 2

Abstract

Purpose of review: This multicentre, cross-sectional study was carried out in the South of France to assess the association between frailty phenotype and antiretroviral therapy (ART) in older persons living with HIV (PLWHIV). Sociodemographic and HIV data, geriatric assessment, comorbidities, behavioral and age-related variables and the five frailty markers of Fried were recorded. Exposure to any pharmacological class of ART and all regimens were retrieved from medical records.

Recent findings: The 509 PLWHIV analysed (72.7% male) received a mean of 6.01 ART regimens and 12.5 years exposure to ART. The prevalence of at least one frailty marker [frail and prefrail phenotype (FPFP)] was 66.4%. Duration of exposure to protease inhibitors and reverse transcriptase inhibitors, number of ART regimens and comorbidities, dyslipidaemia, cancer, depression, falls, disability and pain were significantly associated with FPFP by univariate analysis. In logistic regression multivariable analysis, independent predictors for FPFP were a large number of ART regimens, presence of cancer and pain. No significant association was found with HIV-related parameters neither with ART class and duration.

Summary: A significant association was found between FPFP and a large number of different ART regimens among older PLWHIV. The burden of cancer and pain in these patients shows the importance of comprehensive care.

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老年艾滋病毒感染者的脆弱表型与抗逆转录病毒暴露有关。

综述目的:这项多中心横断面研究是在法国南部进行的，目的是评估老年人艾滋病毒感染者(PLWHIV)的脆弱表型和抗逆转录病毒治疗(ART)之间的关系。记录了社会人口学和HIV数据、老年评估、合并症、行为和年龄相关变量以及Fried的五种虚弱指标。从医疗记录中检索接受任何药理学类别的抗逆转录病毒治疗和所有方案的情况。最新发现:509名PLWHIV患者(72.7%为男性)平均接受6.01次抗逆转录病毒治疗，接受抗逆转录病毒治疗12.5年。至少有一种脆弱标记[虚弱和虚弱前表型(FPFP)]的患病率为66.4%。单变量分析显示，暴露于蛋白酶抑制剂和逆转录酶抑制剂的持续时间、ART治疗方案的数量和合并症、血脂异常、癌症、抑郁、跌倒、残疾和疼痛与FPFP显著相关。在logistic回归多变量分析中，FPFP的独立预测因子是大量的ART治疗方案、癌症的存在和疼痛。与hiv相关参数、抗逆转录病毒治疗类别和持续时间均无显著相关性。总结:在老年plwhv患者中，FPFP与大量不同的ART治疗方案之间存在显著关联。这些患者的癌症和疼痛负担显示了综合护理的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in HIV and AIDS IMMUNOLOGY-INFECTIOUS DISEASES

CiteScore

7.40

自引率

7.30%

发文量

115

审稿时长

6-12 weeks

期刊介绍： Published bimonthly and offering a unique and wide ranging perspective on the key developments in the field, each issue of Current Opinion in HIV and AIDS features hand-picked review articles from our team of expert editors. With six disciplines published across the year – including HIV and ageing, a HIV vaccine, and epidemiology – every issue also contains annotated reference detailing the merits of the most important papers.