Correlation between the efficacy of picosecond-domain laser treatment for solar lentigo and the vascularity in the upper dermis using optical coherence tomography angiography in Asian women

IF 2.2 3区医学 Q2 DERMATOLOGY

Lasers in Surgery and Medicine Pub Date : 2023-09-07 DOI:10.1002/lsm.23724

Yusuke Hara PhD, Masato Ninomiya, Toyonobu Yamashita PhD, Kei Negishi MD, PhD

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Abstract

Objectives

The purpose of this study was to noninvasively confirm the characteristics of the dermal vasculature in patients with solar lentigo (SL) and determine any association with the efficacy of picosecond-domain laser (PSL) treatment.

Methods

Thirteen facial SL lesions in 11 Asian female patients were included in this study and evaluated over 12 weeks. An Nd:YAG laser was used at 532 nm and 750 ps. Skin color and morphological structure were evaluated by ANTERA-3D® and optical coherence tomography (OCT), respectively. To analyze the vascularity in the upper dermis, an OCT angiography (OCTA) algorithm was applied to the OCT data.

Results

After PSL treatment, significant improvement in both hyperpigmentation and abnormally thickened epidermis was observed, but the efficacy varied for each lesion. There was a significant correlation between the change in the melanin index due to PSL treatment and preoperative vascular density in the upper dermis.

Conclusions

To the best of our knowledge, this is the first report to demonstrate a correlation between the efficacy of PSL treatment of SL lesions and the vascularity in the upper dermis. Methods to evaluate the vasculature in the upper dermis may be useful for preoperative prediction of the efficacy of PSL treatment for SL lesions.

查看原文本刊更多论文

利用光学相干断层血管造影术观察亚洲女性使用皮秒域激光治疗日光性白斑的疗效与真皮上层血管的相关性。

研究目的本研究的目的是非侵入性地确认日光性白斑（SL）患者真皮血管的特征，并确定其与皮秒域激光（PSL）治疗效果的关系：本研究共纳入了 11 名亚洲女性患者的 13 处面部日光性白斑病变，并对其进行了为期 12 周的评估。采用波长为 532 nm、时间为 750 ps 的 Nd:YAG 激光。皮肤颜色和形态结构分别由 ANTERA-3D® 和光学相干断层扫描 (OCT) 进行评估。为了分析真皮上层的血管情况，对 OCT 数据采用了 OCT 血管造影（OCTA）算法：结果：PSL治疗后，色素沉着和异常增厚的表皮均有明显改善，但疗效因病变而异。PSL治疗后黑色素指数的变化与术前真皮上层的血管密度有明显的相关性：据我们所知，这是第一份证明 PSL 治疗 SL 病变的疗效与真皮上层血管密度之间存在相关性的报告。评估真皮上层血管的方法可能有助于术前预测 PSL 治疗 SL 病变的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lasers in Surgery and Medicine 医学-外科

CiteScore

5.40

自引率

12.50%

发文量

119

审稿时长

1 months

期刊介绍： Lasers in Surgery and Medicine publishes the highest quality research and clinical manuscripts in areas relating to the use of lasers in medicine and biology. The journal publishes basic and clinical studies on the therapeutic and diagnostic use of lasers in all the surgical and medical specialties. Contributions regarding clinical trials, new therapeutic techniques or instrumentation, laser biophysics and bioengineering, photobiology and photochemistry, outcomes research, cost-effectiveness, and other aspects of biomedicine are welcome. Using a process of rigorous yet rapid review of submitted manuscripts, findings of high scientific and medical interest are published with a minimum delay.

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