The emerging regulatory roles of non-coding RNAs associated with glucose metabolism in breast cancer

IF 12.1 1区医学 Q1 ONCOLOGY

Seminars in cancer biology Pub Date : 2023-10-01 DOI:10.1016/j.semcancer.2023.06.007

Samarth Kansara , Agrata Singh , Abhishesh Kumar Badal , Reshma Rani , Prakash Baligar , Manoj Garg , Amit Kumar Pandey

{"title":"The emerging regulatory roles of non-coding RNAs associated with glucose metabolism in breast cancer","authors":"Samarth Kansara , Agrata Singh , Abhishesh Kumar Badal , Reshma Rani , Prakash Baligar , Manoj Garg , Amit Kumar Pandey","doi":"10.1016/j.semcancer.2023.06.007","DOIUrl":null,"url":null,"abstract":"<div>Altered energy metabolism is one of the hallmarks of tumorigenesis and essential for fulfilling the high demand for metabolic energy in a tumor through accelerating glycolysis and reprogramming the glycolysis metabolism through the Warburg effect. The dysregulated glucose metabolic pathways are coordinated not only by proteins coding genes but also by non-coding RNAs (ncRNAs) during the initiation and cancer progression. The ncRNAs are responsible for regulating numerous cellular processes under developmental and pathological conditions. Recent studies have shown that various ncRNAs such as microRNAs, circular RNAs, and long noncoding RNAs are extensively involved in rewriting glucose metabolism in human cancers. In this review, we demonstrated the role of ncRNAs in the progression of breast cancer with a focus on outlining the aberrant expression of glucose metabolic pathways. Moreover, we have discussed the existing and probable future applications of ncRNAs to regulate energy pathways along with their importance in the prognosis, diagnosis, and future therapeutics for human breast carcinoma.</div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"95 ","pages":"Pages 1-12"},"PeriodicalIF":12.1000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in cancer biology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1044579X23000986","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 1

Abstract

Altered energy metabolism is one of the hallmarks of tumorigenesis and essential for fulfilling the high demand for metabolic energy in a tumor through accelerating glycolysis and reprogramming the glycolysis metabolism through the Warburg effect. The dysregulated glucose metabolic pathways are coordinated not only by proteins coding genes but also by non-coding RNAs (ncRNAs) during the initiation and cancer progression. The ncRNAs are responsible for regulating numerous cellular processes under developmental and pathological conditions. Recent studies have shown that various ncRNAs such as microRNAs, circular RNAs, and long noncoding RNAs are extensively involved in rewriting glucose metabolism in human cancers. In this review, we demonstrated the role of ncRNAs in the progression of breast cancer with a focus on outlining the aberrant expression of glucose metabolic pathways. Moreover, we have discussed the existing and probable future applications of ncRNAs to regulate energy pathways along with their importance in the prognosis, diagnosis, and future therapeutics for human breast carcinoma.

查看原文本刊更多论文

乳腺癌中与糖代谢相关的非编码rna的新调控作用

能量代谢的改变是肿瘤发生的标志之一，对于通过加速糖酵解和通过Warburg效应重新编程糖酵解代谢来满足肿瘤对代谢能量的高需求至关重要。在癌症发生和发展过程中，失调的葡萄糖代谢途径不仅与编码基因的蛋白质协调，而且与非编码RNA（ncRNA）协调。ncRNA负责在发育和病理条件下调节许多细胞过程。最近的研究表明，各种ncRNA，如微小RNA、环状RNA和长非编码RNA，广泛参与了人类癌症中葡萄糖代谢的改写。在这篇综述中，我们证明了ncRNA在癌症进展中的作用，重点概述了葡萄糖代谢途径的异常表达。此外，我们还讨论了ncRNA在调节能量通路方面的现有和可能的未来应用，以及它们在人类乳腺癌预后、诊断和未来治疗中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Seminars in cancer biology 医学-肿瘤学

CiteScore

26.80

自引率

4.10%

发文量

347

审稿时长

15.1 weeks

期刊介绍： Seminars in Cancer Biology (YSCBI) is a specialized review journal that focuses on the field of molecular oncology. Its primary objective is to keep scientists up-to-date with the latest developments in this field. The journal adopts a thematic approach, dedicating each issue to an important topic of interest to cancer biologists. These topics cover a range of research areas, including the underlying genetic and molecular causes of cellular transformation and cancer, as well as the molecular basis of potential therapies. To ensure the highest quality and expertise, every issue is supervised by a guest editor or editors who are internationally recognized experts in the respective field. Each issue features approximately eight to twelve authoritative invited reviews that cover various aspects of the chosen subject area. The ultimate goal of each issue of YSCBI is to offer a cohesive, easily comprehensible, and engaging overview of the selected topic. The journal strives to provide scientists with a coordinated and lively examination of the latest developments in the field of molecular oncology.