Telomere Shortening of Barrett's Esophagus and Esophageal Adenocarcinoma in Japanese Patients.

IF 1.8 4区医学 Q3 ONCOLOGY

Cancer Investigation Pub Date : 2023-09-01 DOI:10.1080/07357907.2023.2245897

Tomomitsu Tahara, Takuya Shijimaya, Jumpei Yamazaki, Takashi Tomiyama, Toshiro Fukui, Makoto Naganuma

引用次数: 0

Abstract

Telomere shortening is deeply involved in many types of cancer. Telomere length of esophageal adenocarcinoma (EAC) and Barrett's esophagus (BE) was examined in Japanese patients. Among BE from cancer free patients (Cancer free), BE from patients with EAC (Adjacent) and EAC tissue (Cancer), Cancer free group presented the longest telomeres, while Cancer group presented the shortest telomeres and Adjacent group presented intermediate telomeres. Direction of endoscopic biopsy, 2 o'clock direction was also significantly associated with shorter telomere length in non-neoplastic BE (p = 0.027). Shortened telomere highlighted the impact of this molecular change in early carcinogenesis in EAC.

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日本巴雷特食管和食管腺癌患者端粒缩短。

端粒缩短与许多类型的癌症密切相关。对日本食管腺癌(EAC)和巴雷特食管(BE)患者的端粒长度进行了检测。在无癌患者(cancer free)、EAC患者(nearby)和EAC组织(cancer)的BE中，无癌组端粒最长，癌组端粒最短，癌组端粒居中。内镜活检方向，2点钟方向与非肿瘤性BE端粒长度较短也显著相关(p = 0.027)。缩短的端粒强调了这种分子变化在EAC早期癌变中的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Investigation 医学-肿瘤学

CiteScore

3.80

自引率

4.20%

发文量

审稿时长

8.5 months

期刊介绍： Cancer Investigation is one of the most highly regarded and recognized journals in the field of basic and clinical oncology. It is designed to give physicians a comprehensive resource on the current state of progress in the cancer field as well as a broad background of reliable information necessary for effective decision making. In addition to presenting original papers of fundamental significance, it also publishes reviews, essays, specialized presentations of controversies, considerations of new technologies and their applications to specific laboratory problems, discussions of public issues, miniseries on major topics, new and experimental drugs and therapies, and an innovative letters to the editor section. One of the unique features of the journal is its departmentalized editorial sections reporting on more than 30 subject categories covering the broad spectrum of specialized areas that together comprise the field of oncology. Edited by leading physicians and research scientists, these sections make Cancer Investigation the prime resource for clinicians seeking to make sense of the sometimes-overwhelming amount of information available throughout the field. In addition to its peer-reviewed clinical research, the journal also features translational studies that bridge the gap between the laboratory and the clinic.