Epigenetic regulation in the commitment of progenitor cells during retinal development and regeneration

IF 2.2 3区生物学 Q4 CELL BIOLOGY

Differentiation Pub Date : 2023-07-01 DOI:10.1016/j.diff.2023.04.002

Wenjie Yin , Xiying Mao , Miao Xu, Mingkang Chen, Mengting Xue, Na Su, Songtao Yuan, Qinghuai Liu

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引用次数: 2

Abstract

Retinal development is initiated by multipotent retinal progenitor cells, which undergo several rounds of cell divisions and subsequently terminal differentiation. Retinal regeneration is usually considered as the recapitulation of retinal development, which share common mechanisms underlying the cell cycle re-entry of adult retinal stem cells and the differentiation of retinal neurons. However, how proliferative retinal progenitor cells perform a precise transition to postmitotic retinal cell types during the process of development and regeneration remains elusive. It is proposed that both the intrinsic and extrinsic programming are involved in the transcriptional regulation of the spatio-temporal fate commitment. Epigenetic modifications and the regulatory mechanisms at both DNA and chromatin levels are also postulated to play an important role in the timing of differentiation of specific retinal cells. In the present review, we have summarized recent knowledge of epigenetic regulation that underlies the commitment of retinal progenitor cells in the settings of retinal development and regeneration.

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视网膜发育和再生过程中祖细胞承诺的表观遗传调控

视网膜发育是由多能视网膜祖细胞启动的，这些细胞经历几轮细胞分裂，随后进行终末分化。视网膜再生通常被认为是视网膜发育的重演，它们有着共同的机制，是成年视网膜干细胞重新进入细胞周期和视网膜神经元分化的基础。然而，增殖性视网膜祖细胞如何在发育和再生过程中精确过渡到有丝分裂后的视网膜细胞类型仍然难以捉摸。提出内在和外在编程都参与了时空命运承诺的转录调控。表观遗传学修饰以及DNA和染色质水平的调控机制也被认为在特定视网膜细胞分化的时间中起着重要作用。在本综述中，我们总结了表观遗传学调控的最新知识，表观遗传学调节是视网膜祖细胞在视网膜发育和再生过程中发挥作用的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Differentiation 生物-发育生物学

CiteScore

4.10

自引率

3.40%

发文量

审稿时长

51 days

期刊介绍： Differentiation is a multidisciplinary journal dealing with topics relating to cell differentiation, development, cellular structure and function, and cancer. Differentiation of eukaryotes at the molecular level and the use of transgenic and targeted mutagenesis approaches to problems of differentiation are of particular interest to the journal. The journal will publish full-length articles containing original work in any of these areas. We will also publish reviews and commentaries on topics of current interest. The principal subject areas the journal covers are: • embryonic patterning and organogenesis • human development and congenital malformation • mechanisms of cell lineage commitment • tissue homeostasis and oncogenic transformation • establishment of cellular polarity • stem cell differentiation • cell reprogramming mechanisms • stability of the differentiated state • cell and tissue interactions in vivo and in vitro • signal transduction pathways in development and differentiation • carcinogenesis and cancer • mechanisms involved in cell growth and division especially relating to cancer • differentiation in regeneration and ageing • therapeutic applications of differentiation processes.