From fetal tendon regeneration to adult therapeutic modalities: TGF-β3 in scarless healing.

IF 2.4 4区医学 Q4 CELL & TISSUE ENGINEERING

Regenerative medicine Pub Date : 2023-10-01 Epub Date: 2023-09-06 DOI:10.2217/rme-2023-0145

Hanyue Li, Shengyu Luo, Hongtao Li, Hongyu Pan, Li Jiang, Yixuan Chen, Hui Chen, Zhenhua Feng, Sen Li

引用次数: 0

Abstract

Tendon injuries are common disorders that can significantly impact people's lives. Unfortunately, the limited regenerative ability of tendons results in tissue healing in a scar-mediated manner. The current therapeutic strategies fail to fully recover the functions of the injured tendons, and as such, the conception of 'scarless healing' has gained prominent attention in the field of regenerative medicine. Interestingly, injured fetal tendons possess the capability to heal through regeneration, which builds an ideal blueprint for adult tendon regeneration. Studies have shown that fetal biochemical cues have the potential to improve adult tendon healing. Here we review the biological factors that contribute to fetal tendon regeneration and how manipulation of these biochemical cues in the adult tendon healing process could achieve regeneration.

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从胎儿肌腱再生到成人治疗模式：TGF-β3在无瘢痕愈合中的作用。

肌腱损伤是一种常见的疾病，会对人们的生活产生重大影响。不幸的是，肌腱有限的再生能力导致组织以瘢痕介导的方式愈合。目前的治疗策略未能完全恢复损伤肌腱的功能，因此，“无瘢痕愈合”的概念在再生医学领域受到了突出关注。有趣的是，受伤的胎儿肌腱具有通过再生愈合的能力，这为成人肌腱再生构建了理想的蓝图。研究表明，胎儿的生化信号有可能改善成人肌腱的愈合。在这里，我们回顾了有助于胎儿肌腱再生的生物学因素，以及在成人肌腱愈合过程中操纵这些生物化学线索如何实现再生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Regenerative medicine 医学-工程：生物医学

CiteScore

4.20

自引率

3.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Regenerative medicine replaces or regenerates human cells, tissue or organs, to restore or establish normal function*. Since 2006, Regenerative Medicine has been at the forefront of publishing the very best papers and reviews covering the entire regenerative medicine sector. The journal focusses on the entire spectrum of approaches to regenerative medicine, including small molecule drugs, biologics, biomaterials and tissue engineering, and cell and gene therapies – it’s all about regeneration and not a specific platform technology. The journal’s scope encompasses all aspects of the sector ranging from discovery research, through to clinical development, through to commercialization. Regenerative Medicine uniquely supports this important area of biomedical science and healthcare by providing a peer-reviewed journal totally committed to publishing the very best regenerative medicine research, clinical translation and commercialization. Regenerative Medicine provides a specialist forum to address the important challenges and advances in regenerative medicine, delivering this essential information in concise, clear and attractive article formats – vital to a rapidly growing, multidisciplinary and increasingly time-constrained community. Despite substantial developments in our knowledge and understanding of regeneration, the field is still in its infancy. However, progress is accelerating. The next few decades will see the discovery and development of transformative therapies for patients, and in some cases, even cures. Regenerative Medicine will continue to provide a critical overview of these advances as they progress, undergo clinical trials, and eventually become mainstream medicine.