Epigenetic lesions drive gliomagenesis

IF 72.5 1区医学 Q1 ONCOLOGY

Nature Reviews Cancer Pub Date : 2023-09-05 DOI:10.1038/s41568-023-00619-w

Gabrielle Brewer

引用次数: 0

Abstract

Rahme et al. establish an in vivo model for low-grade glioma, and use it to demonstrate that Pdgfra insulator loss and Cdkn2a promoter silencing are epigenetic drivers of gliomagenesis.

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表观遗传学病变导致胶质瘤。

Rahme 等人建立了低级别胶质瘤的活体模型，并利用该模型证明了 Pdgfra 绝缘子缺失和 Cdkn2a 启动子沉默是胶质瘤发生的表观遗传驱动因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Cancer 医学-肿瘤学

CiteScore

111.90

自引率

0.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cancer, a part of the Nature Reviews portfolio of journals, aims to be the premier source of reviews and commentaries for the scientific communities it serves. The correct abbreviation for abstracting and indexing purposes is Nat. Rev. Cancer. The international standard serial numbers (ISSN) for Nature Reviews Cancer are 1474-175X (print) and 1474-1768 (online). Unlike other journals, Nature Reviews Cancer does not have an external editorial board. Instead, all editorial decisions are made by a team of full-time professional editors who are PhD-level scientists. The journal publishes Research Highlights, Comments, Reviews, and Perspectives relevant to cancer researchers, ensuring that the articles reach the widest possible audience due to their broad scope.