Association between Serum α-Klotho Levels and Behçet Disease.

Laboratory medicine Pub Date : 2023-09-05 DOI:10.1093/labmed/lmac146

Mohammad Reza Jafari Nakhjavani, Amir Ghorbanihaghjo, Aida Malek Mahdavi, Negin Nemati, Nadereh Rashtchizadeh, Sima Abedi Azar, Alireza Khabbazi

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Abstract

Background: Endothelial dysfunction (ED) has a well-known role in promoting vascular inflammation in Behçet disease (BD). α-klotho is involved in regulation of endothelial function, and its reduction has been reported to be associated with ED.

Objective: To assess serum α-klotho in patients with BD, compared with healthy control individuals.

Methods: In a cross-sectional study, 55 patients with BD and 30 age- and sex-matched healthy controls were enrolled, and their serum levels of α-klotho were measured.

Results: Common clinical symptoms in patients with BD were oral aphthous ulcers, uveitis, and genital ulcers. Median (IQR) serum α-klotho levels in the BD and control groups were 0.30 (0.20-0.70) and 1.00 (0.70-2.52) ng/mL, respectively. The difference was statistically significant (P = .005). No significant correlation was observed between serum α-klotho and age (r = 0.194; P = .14). Serum α-klotho levels in patients with uveitis were significantly lower.

Conclusion: α-klotho may have a role in the pathogenesis of ED and is a potential biomarker for uveitis in BD.

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血清α-Klotho水平与behet病的关系

背景:内皮功能障碍(ED)在behet病(BD)中促进血管炎症的作用是众所周知的。α-klotho参与内皮功能的调节，其降低已被报道与ed有关。目的:评价BD患者血清α-klotho水平，并与健康对照进行比较。方法:采用横断面研究方法，选取55例BD患者和30例年龄、性别匹配的健康对照者，测定其血清α-klotho水平。结果:BD患者常见的临床症状为口腔溃疡、葡萄膜炎和生殖器溃疡。BD组和对照组血清α-klotho水平中位数(IQR)分别为0.30(0.20-0.70)和1.00 (0.70-2.52)ng/mL。差异有统计学意义(P = 0.005)。血清α-klotho与年龄无显著相关性(r = 0.194;p = .14)。葡萄膜炎患者血清α-klotho水平明显降低。结论:α-klotho可能参与ED的发病机制，是BD患者葡萄膜炎的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Laboratory medicine

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