Sequential Chemotherapy Followed by Radiotherapy Versus Concurrent Chemo-Radiation in Muscle Invasive Bladder Cancer.

IF 1.5 4区 医学 Q3 UROLOGY & NEPHROLOGY
Mohammad Hasan Larizadeh, Fateme Arabnejad, Mohammad Reza Ebadzadeh
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引用次数: 0

Abstract

Bladder cancer is diagnosed at older age compared to all other known cancer types. Radical cystectomy after neoadjuvant chemotherapy or tri-modality treatment (consist of TURB, concurrent chemo-radiation) are the standard treatments. Many of the patients cannot receive tri-modality treatment (concurrent chemo-radiation) because of medical comorbidities. The present study assessed the results of sequential use of chemotherapy and radiotherapy versus concurrent use of them in 266 muscle invasive bladder cancer patients. The results showed similar overall survival but lower disease-free survival in the sequential group. Recurrence rate was higher in the concurrent group. The results showed that sequential use of chemotherapy and radiotherapy provides comparable results to concurrent use of them and provides better results than less than tri-modality treatments.

肌肉侵袭性膀胱癌症的顺序化疗后放疗与同期化疗放疗。
与所有其他已知的癌症类型相比,癌症诊断年龄较大。新辅助化疗后的根治性膀胱切除术或三种治疗方式(包括TURB,同时化疗和放疗)是标准的治疗方法。许多患者由于医学合并症而无法接受三种模式的治疗(同时化疗和放疗)。本研究评估了266例癌症肌肉浸润性膀胱癌患者连续使用化疗和放疗与同时使用化疗和放射治疗的结果。结果显示,序贯组的总生存率相似,但无病生存率较低。并发组的复发率较高。结果表明,连续使用化疗和放疗提供了与同时使用化疗和放射治疗相当的结果,并且提供了比少于三种模式的治疗更好的结果。
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来源期刊
Urology Journal
Urology Journal UROLOGY & NEPHROLOGY-
CiteScore
2.60
自引率
6.70%
发文量
44
审稿时长
6-12 weeks
期刊介绍: As the official journal of the Urology and Nephrology Research Center (UNRC) and the Iranian Urological Association (IUA), Urology Journal is a comprehensive digest of useful information on modern urology. Emphasis is on practical information that reflects the latest diagnostic and treatment techniques. Our objectives are to provide an exceptional source of current and clinically relevant research in the discipline of urology, to reflect the scientific work and progress of our colleagues, and to present the articles in a logical, timely, and concise format that meets the diverse needs of today’s urologist. Urology Journal publishes manuscripts on urology and kidney transplantation, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. Accordingly, original articles, case reports, and letters to editor are encouraged.
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