Integrative Analysis of Androgen Receptor Interactors Aberrations and Associated Prognostic Significance in Prostate Cancer.

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY

Urology Journal Pub Date : 2023-10-23 DOI:10.22037/uj.v20i.7469

Zhu Wang, Ying Zhang, Qiong Deng, Jianwen Zhang, Xisheng Wang, Hui Liang

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引用次数: 0

Abstract

Purpose: Much progress has been made by directing against the adrogen receptor (AR) pathway in the treatment of prostate cancer in past decades. However, AR-interactors related metastatic castration resistant prostate cancer eventually developed. Here, we aimed to characterize the aberrations and therapeutic implication in advanced disease.

Materials and methods: STRING database, UALCAN web portal and cBioPortal platform was used to analyze the AR interaction network, gene alterations, as well as the prognostic significance. GO and KEEG analysis was performed to characterize the functional enrichment of the identified AR-interactors.

Results: Ten first shell AR-interactors were identified, among of which FOXA1 and PELP1 was significantly up-regulated, while CCND1, CTNNB1, NCOA4 and HSP90AA1 exhibited a significantly decreased pattern. The median survival period of altered group (n = 227) was 70 months (95% CI, 60-105M), while that of non-altered group (n = 545) was 141 months (95% CI, 115.13-NA, P < 0.001). GO and KEGG enrichment showed that the identified AR-interactors were particularly enriched in prostate cancer and thyroid hormone signaling pathway, as well as endocrine resistance.

Conclusion: The AR-interactors might be useful markers for prostate cancer diagnosis and prognosis, and provide a new sight for revealing the molecular mechanism of CRPC progression.

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癌症前列腺雄激素受体相互作用体异常及其预后意义的综合分析。

目的：在过去的几十年中，在治疗前列腺癌症的过程中，针对肾上腺素受体（AR）通路取得了很大进展。然而，AR-相互作用因子相关的转移性去势耐受性前列腺癌症最终发展。在这里，我们旨在描述晚期疾病的畸变和治疗意义。材料和方法：使用STRING数据库、UALCAN门户网站和cBioPortal平台分析AR交互网络、基因改变以及预后意义。结果：鉴定出10个第一壳AR相互作用体，其中FOXA1和PELP1显著上调，而CCND1、CTNNB1、NCOA4和HSP90AA1表现出显著降低的模式。改变组（n=227）的中位生存期为70个月（95%CI，60-105M），而非改变组（n=545）的中位数生存期为141个月（95%CI，115.13-NA，P＜0.001）。结论：AR-相互作用因子可能是诊断和预后的有用标志物，为揭示CRPC进展的分子机制提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Urology Journal UROLOGY & NEPHROLOGY-

CiteScore

2.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： As the official journal of the Urology and Nephrology Research Center (UNRC) and the Iranian Urological Association (IUA), Urology Journal is a comprehensive digest of useful information on modern urology. Emphasis is on practical information that reflects the latest diagnostic and treatment techniques. Our objectives are to provide an exceptional source of current and clinically relevant research in the discipline of urology, to reflect the scientific work and progress of our colleagues, and to present the articles in a logical, timely, and concise format that meets the diverse needs of today’s urologist. Urology Journal publishes manuscripts on urology and kidney transplantation, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. Accordingly, original articles, case reports, and letters to editor are encouraged.